My research interest focus on the use of statistical genetics to identify genes contributing to risk of complex diseases, which includes most chronic diseases This work falls into the field of genetic epidemiology, and deals with diseases where both genes and environmental risk factors contribute to disease etiology. While I have worked on a wide variety of disease topics (pulmonary disease, diabetes, cancer), I have a long-standing interest in birth defects, particularly cleft lip and cleft palate. I have also recently developed a research interest in methods to detect genes controlling risk to infectious and parasitic diseases.

Statistical genetics, genetic epidemiology, genetics of asthma and allergic diseases, birth defects.

Sull JW, Liang K-Y, Hetmanski JB, Fallin MD, Ingersoll RG, Park JW, Wu-Chou Y-H, Chen PK, Chong SS, Cheah F, Yeow V, Park BY, Jee SH, Jabs WE, Redett R, Jung E, Ruczinski I, Scott AF, Beaty TH. Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations. Genet Epidemiol Mar 20, 2008 (Epub)

Chiu Y-F, Liang K-Y, Chuang L-M, Beaty TH. Incorporation of covariates into multipoint linkage disequilibrium mapping in case-control studies. Genet Epidemiol 32:143-151, 2007.

Jeronimo SMB, Duggal P, Ettinger NA, Nascimento ET, Monteiro GR, Cabral AP, Pontes NN, Lacerda HG, Queiroz PV, Gomes CEM, Pearson RD, Blackwell JM, Beaty TH, Wilson ME. Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: A genomewide scan. J Infect Dis 196:1261-1269, 2007.

Park JW, Yun JE, Part T, Cho E, Jee SH, Jang Y, Beaty TH, Samet JM. Family history of diabetes and risk of atherosclerotic cardiovascular disease in Korean men and women. ATHEROSCLEROSIS, May 8, 2007.(Epub)

Jeronimo SMB, Holst AKB, Jamieson SE, Francis R, Martins DRA, Bezerra FL, Ettinger NA, Nascimento ET, Monteiro GR, Lacerda HG, Miller EN, Cordell HJ, Duggal P, Beaty TH, Blackwell JM, Wilson ME. Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection. GENES IMMUN 8:539-551, 2007.

Gao L, Grant AV, Rafaels N, Stockton-Porter M, Watkins T, Gao P, Chi P, Munoz M, Watson H, Dunston G, Togias A, Hansel N, Sevransky J, Maloney JP, Moss M, Shanholtz C, Brower R, Garcia JGN, Grigoryev DN, Cheadle C, Beaty TH, Mathias RA, Barnes KC. Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. J ALLERGY CLIN IMMUNOL 119:1111-1118, 2007.

Park JW, McIntosh I, Hetmanski JB, Jabs EW, VanderKolk CA, Wu-Chou YH, Chen PK, Chong SC, Jee SH, Fallin MD, Ingersoll R, Scott AF, Beaty TH. Association between IRF6 and Nonsyndromic CL/P in 4 Populations. GENETICS MED 9(4):219-227, 2007.

Lan T-H, Beaty TH, DePaulo JR, McInnis MG. Parent-of-origin effect in the segregation analysis of bipolar affective disorder families. PSYCHIATRIC GENETICS 17(2):93-101, 2007.

Park J, Park BY, Kim HS, Lee JE, Suh L, Nam CM, Kang DR, Kim S, Yun JE, Go EN, Jee SH, Beaty TH. MSX1 polymorphism associated with risk of oral cleft in Korea: evidence from case-parent trio and case-control studies. YONSEI MED J 48:101-108, 2007.

Beaty TH. Invited commentary on two studies of genetic control of birth weight where large data sets were available. AM J EPIDEMIOL 165:753-755, 2007.

Chi PB, Duggal P, Kao WHL, Mathias RA, Grant AV, Stockton ML, Garcia JGN, Ingersoll RG, Scott AF, Beaty TH, Barnes KC, Fallin MD. Comparison of SNP tagging methods using empirical data: Association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population. GENET EPIDEM 30:609-619, 2006

Castellucci L, Menezes E, Oliveira J, Magalhaes A, Guimaraes LH, Lessa M, Ribeiro S, Reale J, Noronha EF, Wilson ME, Duggal P, Beaty TH, Jeronimo S, Jamieson SE, Bales A, Blackwell JM, Ribeiro de Jesus A, Carvalho EM. IL6-174 G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous Leishmaniasis in Brazil. JID 194:519-527, 2006.

Beaty TH, Hetmanski JB, Fallin MD, Park JW, Sull JW, McIntosh I, Liang KY, VanderKolk CA, Redett RJ, Boyadjiev SA, Jabs EW, Chong SS, Cheah FSH, Wu-Chou YH, Chen PK, Chiu YF, Yeow V, Ng ISL, Cheng J, Huang S, Ye X, Wang H, Ingersoll R, Scott AF. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. HUM GENET 120:501-518, 2006.

Park JW, Cai J, McIntosh I, Jabs EW, Fallin MD, Ingersoll R, Hetmanski JB, Vekemans M, Attie-Bitach T, Lovett M, Scott AF, Beaty TH. High throughput SNP and expression analyses of candidate genes for nonsyndromic oral clefts. J MED GENET (in press) 2006.

Gao L, Grant A, Halder I, Brower R, Sevransky J, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Shriver MD, Ingersoll R, Scott AF, Beaty TH, Moitra J, Ma SF, Ye SQ, Barnes KC, Garcia JGN. Novel polymorphisms in the Myosin Light Chain Kinase Gene confer risk for acute lung injury. AM J RESPIR CELL MOL BIOL Jan 6, 2006.

Barnes KC, Grant AV, Baltadzhieva D, Zhang S, Berg T, Zambelli-Weiner A, Anderson W, Nelsen A, Pillai S, Zheng B, Yarnall DP, Ingersoll RG, Scott AF, Fallin MD, Beaty TH, Garcia JGN, Wills-Karp M. Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. GENES AND IMMUNITY 7:27-35, 2006.

Mathias RA, Gao P, Goldstein JL, Wilson AF, Pugh EW, Furbert-Harris P, Dunston G, Malveaux F, Togias A, Barnes KC, Beaty TH, Huang S-K. A graphical assessment of p-values from sliding window haplotye tests of association to identify asthma susceptibility loci on chromosome 11q. BMC GENETICS 7:38, 2006

Park J, Beaty TH, Boyce P, Scott AF, McIntosh I. Comparing whole genome amplification methods and sources of biological sample for SNP genotyping. CLIN CHEM 51:1520-1523, 2005

Shrestha S, Smith MW, Beaty TH, Strathdee SA. Theory and methodology for genetic determination of biological mixtures. ANN EPI 15:29-38, 2005.