His research and teaching focus on patient outcomes and quality of care.

He was among the first to measure quality of life outcomes in people with HIV. He was one of the founders of the Outcomes Committe of the AIDS Clinical Trials Group of the NIH ACTG. He developed the MOS-HIV Health Survey, a leading measure of health related quality of life for people with HIV that is used widely in international trials and research studies.

He has studied the handling of medical errors since 1998, and has published influential papers including “Do house officers learn from their mistakes” in JAMA in 1991, “To tell the truth - ethical and practical issues in disclosing medical mistakes to patients” in the Journal of General Internal Medicine and “Medical error: the second victim” in the BMJ. He was co-principal investigator of an AHRQ funded grant to develop a web-based incident reporting system for intensive care units.

He is principal investigator of the AHRQ-funded Johns Hopkins DEcIDE center to conduct rapid, policy relevant studies of comparative effectiveness. He is studying video vignettes of disclosures to patient and their families, and developed an award-winning educational video on disclosure “Removing insult from injury: disclosing adverse events.”

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Patient Safety, Disclosure, Quality of Life, Adherence

Huang IC, Wu AW, Finnern HW, Thijs H, Gathe JC, Fairclough DL. Health-related quality of life and tolerability in treatment-experienced HIV-1-infected patients on tipranavir versus comparator regimens. Antivir Ther. 2008;13(1):15-25.

Wu AW, Lipshutz AK, Pronovost PJ. Effectiveness and efficiency of root cause analysis in medicine. JAMA. 2008 Feb 13;299(6):685-7.

Mannheimer S, Thackeray L, Huppler Hullsiek K, Chesney M, Gardner EM, Wu AW, Telzak EE, Lawrence J, Baxter J, Friedland G; Terry Beirn Community Program for Clinical Research on AIDS. A randomized comparison of two instruments for measuring self-reported antiretroviral adherence. AIDS Care. 2008 Feb;20(2):161-9.

Mannheimer SB, Wold N, Gardner EM, Telzak EE, Huppler Hullsiek K, Chesney M, Wu AW, MacArthur RD, Matts J, Friedland G; Terry Beirn Community Programs for Clinical Research on AIDS. Mild-to-moderate symptoms during the first year of antiretroviral therapy worsen quality of life in HIV-infected individuals. Clin Infect Dis. 2008 Mar 15;46(6):941-5.

Huang IC, Frangakis C, Atkinson MJ, Willke RJ, Leite WL, Vogel WB, Wu AW. Addressing ceiling effects in health status measures: a comparison of techniques applied to measures for people with HIV disease. Health Serv Res. 2008 Feb;43(1 Pt 1):327-39.

Reynolds NR, Sun J, Nagaraja HN, Gifford AL, Wu AW, Chesney MA. Optimizing measurement of self-reported adherence with the ACTG Adherence Questionnaire: a cross-protocol analysis. J Acquir Immune Defic Syndr. 2007 Dec 1;46(4):402-9.

Fairclough DL, Thijs H, Huang IC, Finnern HW, Wu AW. Handling missing quality of life data in HIV clinical trials: what is practical? Qual Life Res. 2008 Feb;17(1):61-73.

Burman WJ, Grund B, Roediger MP, Friedland G, Darbyshire J, Wu AW; SMART Study Group. The impact of episodic CD4 cell count-guided antiretroviral therapy on quality of life. J Acquir Immune Defic Syndr. 2008 Feb 1;47(2):185-93.

Segal JB, Griswold M, Achy-Brou A, Herbert R, Bass EB, Dy SM, Millman AE, Wu AW, Frangakis CE. Using propensity scores subclassification to estimate effects of longitudinal treatments: an example using a new diabetes medication. Med Care. 2007 Oct;45(10 Supl 2):S149-57.

Sinopoli DJ, Needham DM, Thompson DA, Holzmueller CG, Dorman T, Lubomski LH, Wu AW, Morlock LL, Makary MA, Pronovost PJ. Intensive care unit safety incidents for medical versus surgical patients: a prospective multicenter study. J Crit Care. 2007 Sep;22(3):177-83.

Jones JB, Snyder CF, Wu AW. Issues in the design of Internet-based systems for collecting patient-reported outcomes. Qual Life Res. 2007 Oct;16(8):1407-17.

Unruh ML, Buysse DJ, Dew MA, Evans IV, Wu AW, Fink NE, Powe NR, Meyer KB; Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study. Sleep quality and its correlates in the first year of dialysis. Clin J Am Soc Nephrol. 2006 Jul;1(4):802-10.

Simon AE, Wu AW, Lavori PW, Sugarman J. Preventive misconception: its nature, presence, and ethical implications for research. Am J Prev Med. 2007 May;32(5):370-4.

Okelo SO, Wu AW, Merriman B, Krishnan JA, Diette GB. Are physician estimates of asthma severity less accurate in black than in white patients? J Gen Intern Med. 2007 Jul;22(7):976-81. Huang IC, Willke RJ, Atkinson MJ, Lenderking WR, Frangakis C, Wu AW. US and UK versions of the EQ-5D preference weights: does choice of preference weights make a difference? Qual Life Res. 2007 Aug;16(6):1065-72.

Plantinga LC, Fink NE, Jaar BG, Huang IC, Wu AW, Meyer KB, Powe NR. Relation between level or change of hemoglobin and generic and disease-specific quality of life measures in hemodialysis. Qual Life Res. 2007 Jun;16(5):755-65. Epub 2007 Feb 8.

Pronovost PJ, Thompson DA, Holzmueller CG, Lubomski LH, Dorman T, Dickman F, Fahey M, Steinwachs DM, Engineer L, Sexton JB, Wu AW, Morlock LL. Toward learning from patient safety reporting systems. J Crit Care. 2006 Dec;21(4):305-15.

Wu AW, Snyder CF, Huang IC, Skolasky R, McGruder HF, Celano SA, Selnes OA, Andrade AS. A randomized trial of the impact of a programmable medication reminder device on quality of life in patients with AIDS. AIDS Patient Care STDS. 2006 Nov;20(11):773-81.

Wu AW, Sexton JB, Pronovost PJ. Partnership with patients: a prescription for ICU safety. Chest. 2006 Nov;130(5):1291-3.

Sedrakyan A, Wu AW, Parashar A, Bass EB, Treasure T. Off-pump surgery is associated with reduced occurrence of stroke and other morbidity as compared with traditional coronary artery bypass grafting: a meta-analysis of systematically reviewed trials. Stroke. 2006 Nov;37(11):2759-69. Epub 2006 Sep 28.

Reynolds NR, Neidig JL, Wu AW, Gifford AL, Holmes WC. Balancing disfigurement and fear of disease progression: Patient perceptions of HIV body fat redistribution. AIDS Care. 2006 Oct;18(7):663-73.

Stokes SL, Wu AW, Pronovost PJ. Ethical and practical aspects of disclosing adverse events in the emergency department. Emerg Med Clin North Am. 2006 Aug;24(3):703-14.