1. Malhotra D, Thimmulappa R., Vij N., Sussan T., Merali S., Zhang Li, Kelsen S., Myers A., Wise R., Tuder RM, and Biswal S. (2009) Heightened endoplasmic reticulum stress in COPD lungs: the role of Nrf2 regulated proteasomal activity. Am J Respir Crit Care Med. (In press)
2. Rangasamy T, Williams MA, Bauer S, Trush M, Emo J, Georas N, and Biswal S, (2009) Nrf2 Inhibits the Maturation of Murine Dendritic Cells by the Ragweed Allergen. Am. J. Respir. Cell. Mol. Biol. (in press)
3. Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, and Biswal S. (2009) Targeting Nrf2 with the Triterpenoid CDDO-Imidazolide Attenuates Cigarette Smoke-Induced Emphysema and Cardiac Dysfunction in Mice. Proc. Natl. Acad. Sci. 106(1):250-5
4. Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S. (2009) Nrf2 Dependent Sulfiredoxin-1 Expression Protects Against Cigarette Smoke induced Oxidative Stress in Lungs. Free Radic Biol Med. 1;46(3):376-86
5. Harvey CJ, Thimmulappa RK, Singh A, Blake DH, Ling G, Wakabayashi N, Fujii J, Myers AC, and Biswal S. (2009) Nrf2 regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress. Free Radic Biol Med. 46(4)443-53
6. Rangasamy T, Misra V, Zhen L, Tankersley CG, Tuder, RM, and Biswal, S. (2009) Cigarette Smoke-Induced Emphysema in A/J mice is Associated with Pulmonary Oxidative Stress, Apoptosis of lung Cells, and Global Alterations in Gene Expression. Amer. J. Physiol. Lung Cell. Mol. Physiol. 296(6):L888-L900
7. Blake, DJ, Singh, A, Kombairaju, P, Malhotra, D, Mariani, TJ, Tuder, RM and Biswal, S. (2009) Deletion of Keap1 in lung attenuates acute cigarette smoke-induced oxidative stress and inflammation Am J Respir Cell Mol Biol (In press)
8. An SS, Kim J, Ahn K, Trepat X, Drake KJ, Kumar S, Ling G, Purington C, Rangasamy T, Kensler TW, Mitzner W, Fredberg JJ, and Biswal S. Cell stiffness, contractile stress and the role of extracellular matrix. (2009) Biochem Biophys Res Comm. 382(4):697-703.
9. Norihiro Nagai,N., Thimmulappa,R.K., Cano,M., Fujihara,M., Izumi-Nagai,K., Kong, X., Sporn, M.B., Kensler, T.W., Biswal,S. Handa, J.T. (2009) Nrf2 is a Critical Modulator of the Innate Immune Response in a Model of Uveitis Free Radic Biol Med. 47(3):300-6
10. McGrath-Morrow S, Lauer T, Yee M, Neptune E, Podowski M, Thimmulappa R, OReilly M, and Biswal S. (2009) Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol. 296(4):L565-73.
11. Podowski,M., Calvi,C.L., Cheadle,C., Tuder, R.M., Biswal,S., Neptune, E. R., (2009) Complex integration of matrix, oxidative stress and apoptosis in genetic emphysema Am. J. Pathol. 175(1):84-96
12. Le A, Zielinski R, He C, Crow MT, Biswal S, Tuder RM, and Becker PM (2009) Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema Am J Respir Crit Care Med. (In Press)
13. Bivalacqua TJ, Sussan TE, Gebska MA, Strong TD, Berkowitz DE, Biswal S, Burnett AL, Champion HC. (2009) Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in mouse model of secondhand smoke induced erectile dysfunction. J. Urol 181(2):899-906
14. Sussan TE, Jun J, Thimmulappa R, Bedja D, Antero M, Gabrielson KL, Polotsky VY, Biswal S. (2008) Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS ONE. 3(11):e3791
15. Singh A, Boldin-Adamsky S, Thimmulappa RK, Rath SK, Ashush H, Coulter J, Blackford A, Goodman SN, Bunz F, Watson WH, Gabrielson E, Feinstein E, and Biswal S. (2008) RNAi-mediated silencing of nuclear factor erythroid-2-related factor gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res. 68:(19): 7975-84
16. Malhotra D, Thimmulappa RK, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S. (2008) Decline in NRF2 regulated antioxidants in COPD lungs due to loss of its positive regulator DJ-1. Am J Respir Crit Care Med. 178(6):592-604
17. Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN. (2008) Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. J Immunol. 181(7):4545-59
18. Taylor RC, Acquaah-Mensah G, Singhal M, Malhotra D, Biswal S. (2008) Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress. PLoS Comp Biol. 4(8):e1000166
19. Thimmulappa RK, Rangasamy T, Alam J, Biswal S. (2008) Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA Adducts in lungs. Med. Chem. 4(5):473-81
20. Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, Paolocci N, Champion HC, Kass DA. (2008) Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation. 117(20):2626-36
21. Saleem S, Zhuang H, Biswal S, Christen Y, Dor S. (2008) Ginkgo Biloba Extract Neuroprotective Action Is Dependent on Heme Oxygenase 1 in Ischemic Reperfusion Brain Injury. Stroke. 39(12):3389-96
22. Fujihara M, Nagai N, Sussan TE, Biswal S, Handa JT. (2008) Chronic Cigarette Smoke Causes Oxidative Damage and Apoptosis to Retinal Pigmented Epithelial Cells in Mice. PLoS ONE 3(9): e3119
23. Huang K, Rabold R, Abston E, Schofield B, Misra V, Galzicka E, Lee H, Biswal S, Mitzner W, Tankersley CG. (2008) Effects of Leptin Deficiency on Postnatal Lung Development in Mice. J Appl Physiol. 105(1):249-59
24. Traore, K, Sharma, R, Thimmulappa RK, Watson WH, Biswal S, Trush MA. (2008) Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: Role in signaling TPA-induced growth arrest in ML-1 cells. J Cell Physiol. 216(1):276-85
25. Malhotra S, Shakya G, Kumar A, Vanhoecke BW, Cholli AL, Raj HG, Saso L, Ghosh B, Bracke ME, Prasad AK, Biswal S, and Parmar VS. (2008) Antioxidant, Antiinflammatory and Antiinvasive Activities of Biopolyphenolics. ARKIVOC (vi) 119-139
26. McGrath-Morrow S, Rangasamy T, Cho C, Sussan T, Neptune E, Wise R, Tuder RM, Biswal S. (2008) Impaired Lung Homeostasis in Neonatal Mice Exposed to Cigarette Smoke. Am J Respir Cell Mol Biol. 38(4):393-400
27. Kensler TW, Wakabayaski N, Biswal S. (2007) Cell survival responses to Environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47:89-116
28. Misra V, Lee H, Singh A, Huang K, Thimmulappa RK, Mitzner W, Biswal S, and Tankersley CG. (2007) Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes. Physiol Genomics 31(3):429-40
29. Papaiahgari S, Yerrapureddy A, Reddy SR, Reddy NM, Dodd-O JM, Crow MT, Grigoryev DN, Barnes K, Tuder RM, Yamamoto M, Kensler TW, Biswal S, Mitzner W, Hassoun PM, Reddy SP. (2007) Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med. 176(12):1222-35
30. Biswal S, and Remick DG. (2007) Sepsis: Redox Mechanisms and Therapeutic Opportunities. Antioxid Redox Signal 9(11):1959-62
31. Thimmulappa R, Fuchs R, Malhotra D, Scollick C, Traore K, Bream J, Trush M, Liby K, Sporn MB, Kensler T, and Biswal S. (2007) Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal; 9(11):1963-70
32. Shin S, Wakabayashi N, Misra V, Biswal S, Lee GW, Agoston ES, Yamamoto M, and Kensler TW. (2007) Nrf2 modulates AHR signaling: influence on adipogenesis. Mol Cell Biol; 27(20):7188-97
33. Reddy NM, Kleeberger SR, Cho HY, Yamamoto M, Kensler TW, Biswal S, Reddy SP. (2007) Deficiency in Nrf2-GSH Signaling Impairs Type II Cell Growth and Enhances Sensitivity to Oxidants. Am J Respir Cell Mol Biol. 37(1):3-8
34. Rulli SJ Jr, Hibbert CS, Mirro J, Pederson T, Biswal S, Rein A. (2007) Selective and non-selective packaging of cellular RNAs in retrovirus particles. J Virol. 81(12):6623-31
35. Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, and Dore S. (2007) Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. Neuroscience 147(1):53-59
36. Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, and Dore S. (2007) Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med 43(3):408-14
37. Huang K, Rabold R, Schofield B, Mitzner W, Lee H, Biswal S, Tankersley CG. (2007) Variation in senescent-dependent lung changes in inbred mouse strains. J Appl Physiol. 102(4):1632-9
38. Balbir A, Lee H, Okumura M, Biswal S, Fitzgerald RS, Shirahata M. (2007) A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Am J Physiol Lung Cell Mol Physiol. 292(3):L704-15
39. Thimmulappa RK, Scollick C, Trarore K, Yates M, Trush MA, Liby KT, Spoorn M, Yamamoto M, Kensler TW and Biswal S. (2006) Nrf2 dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun 351(4):883-889. H
40. Thimmulappa RK, Lee H, Rangasamy T, Kensler TW, Yamamoto M, Reddy SP, and Biswal S. (2006) Nrf2 is a critical regulator of innate immune response and survival during experimental sepsis. J. Clin. Invest. 116(4):984-995
41. Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman, JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S. (2006) Dysfunctional KEAP1 Nrf2 Interaction in Non-Small-Cell Lung Cancer. PLoS Medicine 3(10): e420
42. Singh A, Rangasamy T, Thimmulappa RK, Lee H, Osburn WO, Brigelius-Flohe R, Kensler TW, Yamamoto M, Biswal S. (2006) Glutathione Peroxidase 2, the Major Cigarette smoke-inducible Isoform of GPX in Lungs is Regulated by Nrf2. Am J Respir Cell Mol Biol 35(6):639-50
43. Tuder RM, Yoshida T, Fijalkowka I, Biswal S, Petrache I. (2006) Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. Proc Am Thorac Soc. 3(8):673-9
44. Biswal S, Rangasamy T, Tuder RM. (2006) Modifier Role of Nrf2 in Cigarette Smoke-induced Emphysema. Proc Am Thorac Soc 3:543a
45. Yoshida T, Rangasamy T, Biswal S, Petrache I, Mett I. et al. (2006) Role of RTP801, a suppressor of the mTOR Pathway, in Cigarette Smoke-induced Pulmonary Injury in Mice. Proc Am Thorac Soc 3:551a-2
46. Osburn, WO, Wakabayashi N, Misra V, Nilles T, Biswal S, Trush MA, Kensler, TW. (2006) Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch Biochem Biophys. 454(1):7-15
47. Mensah GK, Misra V, Biswal S. (2006) Ethanol Sensitivity: A Central Role for CREB Transcription Regulation in the Cerebellum. BMC Genomics 7(1):308
48. Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN and Biswal S. (2005) Disruption of Nrf2 Enhances susceptibility to Severe Airway Inflammation and Asthma in Mice. J. Exp. Med. 202(1):47-59
49. Tian J, Ishibashi K, Ishibashi K, Reiser K, Grebe R, Biswal S, Gehlbach P, Handa JT. (2005) Advanced Glycation Endproduct-Induced Aging of the Retinal Pigment Epithelium and Choroid: A Comprehensive Transcriptional Response. Proc Natl Acad Sci. 102(33):11846-51
50. Chen H, Rubin E, Zhang H, Chung S, Jie CC, Garrett E, Biswal S, Sukumar S. (2005) Identification of transcriptional targets of HOXA5. J Biol Chem. 280(19):19373-80
51. Irizarry R, Warren D, Spencer F, Kim IF, Biswal S, Frank BC, Gabrielson E, Garcia JGN, Geoghegan J, Germino G, Griffin C, Hilmer SC, Hoffman E, Jedlicka AE, Kawasaki E, Martinez-Murillo F, Morsberger L, Lee H, Petersen D, Quackenbush J, Scott A, Wilson M, Yang Y, Ye SQ, Yu W. (2005) Multiple-laboratory comparisons of microarray platforms. Nature Methods. 2(5):345-50
52. Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma S, Kensler TW, Yamamoto M, Petrache I, Tuder RM and Biswal S. (2004) Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice, J. Clin. Invest. 114(9):1248-1259
53. Biswal S, Maxwell T, Rangasamy T, Kehrer JP. (2003) Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein. Carcinogenesis, 24(80):1401-1406
54. Srisuma S, Biswal S, Mitzner WA, Gallagher SJ, Mai KH and Wagner EM. (2003) Identification of genes promoting angiogenesis in mouse lung by transcriptional profiling. Am J Respir Cell Mol Biol. 29(2):172-179
55. Wu XL, Biswal S and Kehrer JP (2003) Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis, Cell Biology and Toxicology, 19(3):135-43
56. Thimmulappa RK, Mai KH, Srisuma S, Kensler TW Yamamoto M and Biswal S. (2002) Identification of Nrf2 Regulated Genes Induced by the Chemopreventive Agent Sulforaphane by Oligonucleotide Microarray. Cancer Res. 62(18):5196-5203
57. Rangasamy T, Rajesh Kumar T, Mai KH and Biswal S. (2002) Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells. Toxicol Lett, 132(1):27–36
58. Biswal SS, Mensah GK, Datta K, Wu, XL and Kehrer JP. (2002) Inhibition of cell proliferation and AP-1 activity by acrolein in human A549 lung adenocarcinoma cells due to thiol imbalance and covalent modifications Chem. Res. Toxicol.15(2):180-186
59. Biswal SS, Datta K and Kehrer JP. (2001) Association between bcl-xL and 5-lipoxygenase activating protein (FLAP) levels in IL-3 dependent FL5.12 cells Toxicology-160(1-3):97-103
60. Kehrer JP, Biswal SS, Thuillier P, Datta K, Fischer S and Vanden Heuvel JP. (2001) Inhibition of Peroxisome Proliferator Activated Receptor alpha(PPARa) by MK886. Biochem. J. 356 (3) 899-906
61. Datta K, Kern JC, Biswal SS and Kehrer JP. (2001) Proteolytic Loss of bcl-x(L) in FL5.12 Cells Undergoing Apoptosis Induced by MK886. Toxicol Appl Pharmacol 174(3):273-281
62. Kehrer JP and Biswal SS. (2000) The molecular effects of acrolein. Toxicol. Sci. 57(1), 6-15. H
63. Biswal SS, Datta K, Acquaah-Mensah GK and Kehrer JP. (2000) Changes in ceramide sphingomyelin and p53 following fludarabine treatment of human chronic B-cell leukemia cells. Toxicology. 154(1-3): 45-53
64. Biswal SS, Datta K, Shaw SD, Feng X, Robertson JD and Kehrer JP. (2000) Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells Toxicol. Sci. 53(1):77-83
65. Horton ND, Biswal SS, Corrigan LL, Bratta J and Kehrer JP. (1999) Acrolein causes Inhibitor kB independent decreases in Nuclear factor-kB activation in human lung adenocarcinoma (A549) cells. J. Biol. Chem. 274(14):9200-9206
66. Datta K, Biswal SS, Kehrer JP. (1999) The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP. Biochem. J. 340(2):371-375
67. Robertson JD, Datta K, Biswal SS and Kehrer JP. (1999) HSP70 antisense oligomer enhances proteasome inhibitor-induced apoptosis. Biochem. J. 344(2):477-485
68. Datta K, Biswal SS, Xu J, Towndrow KM, Feng X and Kehrer JP. (1998) A relationship between 5 lipoxygenase activating protein (FLAP) and bcl-xL expression in murine pro B-lymphocytic FL5.12 cells. J. Biol. Chem. 273(43): 28163-28169
69. Ahn YT, Wu XL, Biswal SS, Velmurugan S, Volkert FC, and Jayaram M. (1997) The 2 um-plasmid-encoded Rep1 and Rep2 proteins interact with each other and colocalize to the Saccharomyces cerevisiae nucleus. J Bacteriol 179(23): 7497-506
70. Biswas S, Bhelwa A, Itoop A, Biswal S and Nath N. (1994) In vitro effect of a diabetic serum factor on generation of superoxide free radical, its quenching ability and lysosomal degranulation in normal polymorphonuclear leucocytes. Ind J. Clin Biochem. 9: 3-8
71. Biswas S, Bhelwa A, Itoop A, Biswal S and Nath N. (1994) Effect of diabetic serum factor on polymorphonuclear leukocyte membrane hydrophobicity and particle internalization. Ind J Clin Biochem 9 :9-15
72. Nath N, Biswas S, Bhelwa A, Itoop A and Biswal S. (1993) Plausible involvement of a diabetic serum factor in neutrophil membrane pathology. Ind J Biochem Biophys 30(4): 244-246
