My training is in medicine, experimental pathology, and immunology. My research activities center on the cellular immunology and pathogenesis of infection with human immunodeficiency virus (HIV), and I also direct the flow cytometry core laboratory for the School of Hygiene and Public Health. Some specific research interests are:

Regulation of T Cell turnover and homeostasis in HIV infection.

Effects of illicit drugs on immune function.

Early events in HIV infection

Human immunodeficiency virus, immune assessment, immune deficiency, T-cells, flow cytometry, cell sorting, pathogenesis of HIV

Margolick, J.B., Muñoz, A., Donnenberg, A., Park, L.P., Galai, N., Giorgi, J.V., O'Gorman, M., Ferbas, J. and the Multicenter AIDS Cohort Study. Failure of T cell homeostasis preceding AIDS in HIV-1 infection. Nature Medicine 1:674-680, 1995.

Galai, N., Park, L.P., Wesch, J., Visscher, B., Riddler, S., Margolick, J.B. Effect of smoking on the clinical progression of HIV-1 infection. J, Acquir. Immune Defic. Syndr. Hum. Retrovirol. 14:451-458, 1997.

Gange, S.J., Muñoz, A., Chmiel, J.S., Donnenberg, A.D., Detels, R., Margolick, J.B. Identification of inflections in T-cell counts among HIV-1-infected individuals and relationship with progression to clinical AIDS. Proc. Nat. Acad. Sci. 95:10848-10853, 1998.

Shankarappa, R., Margolick, J.B., Gange, S.J., Rodrigo, A.G., Upchurch, D., Farzadegan, H., Gupta, P., Rinaldo, C.R., Learn, G.H., He, X.; Huang, X.L, Mullins, J.I. Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection. J. Virol. 73:10489-10502, 1999.

Maas, J., Gange, S.J., Schuitemaker, H., Coutinho, R., van Leeuwen, R., Margolick, J.B. Strong association between failure of T cell homeostasis and the syncytium-inducing phenotype among HIV-1-infected men in the Amsterdam Cohort Study. AIDS 14:1155-1161, 2000.

Gange, S.J., Mellors, J.W., Lau, B., Detels, R., Phair, J.P., Muñoz, A., Margolick, J.B. Longitudinal patterns of HIV-1 RNA among individuals with late disease progression. AIDS Res Hum Retroviruses 17:1223-1229, 2001.

Gange, S.J.,Lau, B., Phair, J.,Riddler, S.A.,Detels, R.,Margolick, J.B. Rapid declines in total lymphocyte count and hemoglobin in HIV infection begin at CD4 lymphocyte counts that justify antiretroviral therapy. AIDS 17:119-131, 2003.

Mayer, K..H., Hogan, J.W., Smith, D., Klein, R.S., Schuman, P., Margolick, J.B., Korkontzelou, C., Farzedegan, H., Vlahov, D., Carpenter, C.C.J. Clinical and immunological progression in HIV-infected U.S. women before and after the introduction of highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr 33:614-624, 2003