Research is focused on child health in developimg countries, especially diarrheal and respiratory diseases. This has included clinical trials of improved and simplified treatments for acute diarrhea and cholera, including oral rehydration therapy, and on the evaluation of vaccines for cholera, typhoid fever, rotavirus, Haemophilus influenzae type b, and pneumococcal disease. Current collaboration is with the World Health Organization Department of Child and Adolescent Health and Development. Previous research was on mucosal immunity inanimal models, studying especially the cellular kinetics of the intestinal IgA immune response and determinants of the mucosal distribution of that response.

International Health, child health in developimg countries, especially diarrheal and respiratory diseases. This has included clinical trials of improved and simplified treatments for acute diarrhea, and of vaccines for diarrheal diseases and respiratory infections.

Research Career Development Award - 1971-1976

Pollin Prize in Pediatric Research - 2002

1.Gore, S. M., Fontaine, O., and Pierce, N. F. Impact of rice-based oral rehydration solution on stool output and duration of diarrhoea: Meta-analysis of thirteen clinical trials. British Medical Journal 304: 287-291, 1992.

2. Bhan, M. K., Fontaine, O., Gore, S. M., Grange, A. N., Jalan, K. N., Kassem, A. S., Khin Maung U, Mahalanabis, D., Pierce, N. F., Pizarro, D., Romer, H., Salazar-Lindo, E., and Santos Ocampo, P. Impact of glycine-containing oral rehydration solutions on stool output and duration of diarrhoea: Meta-analysis of seven clinical trials. Bull. Wld. Hlth. Org. 69: 541-548, 1992.

3. Glass, R. I., Claeson, M., Blake, P. A., Waldman, R. J., and Pierce, N. F. Twenty years of cholera in Africa: Lessons on transmission and control for South America. Lancet 338: 791-795, 1991.

4. Richards, L., Claeson, M., and Pierce, N. F. Management of acute diarrhoea in children. Pediatric Infectious Diseases Journal 12: 5-9, 1993.

5. El-Mougi, M., El-Akkad, N., Hendawi, A., Hassan, M., Amer, A., Fontaine, O., and Pierce, N. F. Is low osmolarity ORS solution more efficacious than standard ORS solution? J. Pediatric Gastroenterology and Nutrition 19: 83-86, 1994.

6. Bhan, M. K., Mahalanabis, D., Fontaine, O., and Pierce, N. F. Clinical trials of improved oral rehydration salt formulations: a review. Bull. Wld. Hlth. Org. 72: 945-955, 1994.131. Bhan, M.K., Gore, S.M., Grange, A.N., Jalan, K.N., Kassem, A.S., Khin Maung U, Mahalanabis, D., Pizarro, D., Römer, H., Salazar-Lindo, E., Santos Ocampo, P., Fontaine, O., and Pierce, N.F. Impact of glycine-containing ORS solutions on stool output and duration of diarrhoea: a meta-analysis of seven clinical trials. Bull. Wld. Hlth. Org. 69: 541-548, 1991.

7. Bhan, M.K., Chea Woo, E., Fontaine, O., Maulen-Radovan, I., Pierce, N.F., and Ribeiro, H. Multicentre evaluation of reduced-osmolarity oral rehydration salts solution. Lancet 345: 282-285, 1995.

8. El-Mougi, M., Hendawi, A., Koura, H., Hegazi, E., Fontaine, O., and Pierce, N.F. Effect of sugar malabsorption on efficacy of standard glucose-based and reduced osmolarity maltodextrin-based oral rehydration solutions. Bull. Wld. Hlth. Org. 74: 471-477, 1996.

9. Gore, S.M., Fontaine, O., and Pierce, N.F. Efficacy of rice-based oral rehydration. Lancet 348: 193-194, 1996.

10. Levine, O.S., Schwartz, B., Pierce, N. and Kane, M. Development, evaluation and implementation of Haemophilus influenzae type b vaccines for young children in developing countries: current status and priority actions. Pediatr Infect Dis J 17:10-31, 1998.

11. Fontaine, O., Gore, S.M. and Pierce, N.F. Diarrhoea treatment: rice-based oral rehydration solution. The Cochrane Library 4,1998.

12. Pierce, N.F., Fontaine, O. and Sack, R.B. Amylase-resistant starch plus oral rehydration solution for cholera. New England Journal of Medicine 342: 1995-1996, 2000.

13. Nolan, T., Angos, P., Cunha, A.J.L.A., Muhe, L., Qazi, S., Simoes, E.A.F., Tamburlini, G., Weber, M., and Pierce, N.F. Quality of hospital care for seriously ill children in less-developed countries. The Lancet 357: 106-110, 2001.

14. Pierce, N.F. How much has ORT reduced child mortality? J Health Popul Nutr 19:1-3, 2001

15. Klugman KP, Madhi SA, Huebner RE, Kohberger R, Mbelle N, Pierce NF. Prevention of pneumonia, invasive disease and antibiotic-resistant invasive pneumococcal disease by a 9-valent pneumococcal conjugate vaccine: efficacy in both HIV-infected and uninfected children. New England Journal of Medicine 349:1341-1348, 2003.