1. Clinical trials in chronic obstructive lung diseases. These include long-term studies of inhaled corticosteroids in mild to moderate COPD (lung Health Study II), effect of anti-inflammatory agents on lung growth in mild to moderate asthmatic children (CAMP), safety and effectiveness of lung volume reduction surgery for emphysema (LVRS Trial), and studies of treatment of pregnant asthmatic women.

2. Scleroderma and the lung. Studies of the clinical epidemiology, pathobiology, and treatment of interstitial lung disease in patients with Scleroderma.

Clinical trials in chronic obstructive lung diseases

Yurovsky VV, FM Wigley, RA Wise, and B White. Skewing of the CD8- T-cell repertoire in the lungs of patients with systemic sclerosis. Human Immunology 48: 84-97, 1996.

Tashkin DP, MD Altose, JE Connett, RE Kanner, WW Lee, RA Wise. Methacholine reactivity predicts changes in lung function over time in smokers with mild to moderate airflow limitation. Am J Respir Crit Care Med 153(6): 1802-1811, 1996.

Todd NW, RA Wise. Respiratory complications in the collagen vascular diseases. Clinical Pulmonary Medicine 3(2): 101-112, 1996.

Wise RA, GG Weinmann. Chronic Obstructive Pulmonary Disease. In: The Principles and Practice of Medicine, 23rd Edition. Stobo JD, DB Hellmann, PW Ladenson, BG Petty, and TA Traill (eds). Appleton & Lange, Norwalk, CT pp 133 139, 1996.

Wise RA. Pulmonary function during pregnancy. In: Asthma and Allergy in Pregnancy and Early Infancy. Schatz M, RS Zeiger, HN Claman, eds. Marcel Dekker, Inc. (In Press) 1996.