Brief description of current research activities:

My research interests have always been focused on the structural basis of physiologic and pathologic function in the lung. Current work is concerned with understanding the static and dynamic behavior of airway smooth muscle, with particular emphasis on the interactions with the lung parenchyma. Additional funded work involves evaluating methods of permanently impairing the ability of airway smooth muscle to shorten, as a possible treatment of asthma. I also have a keen interest in understanding and developing methods to assess pulmonary function in the mouse, and these functional studies in mice are directed toward investigating mechanisms of alveolar destruction with age or environmental insults.

Environmental Health Sciences, asthma, emphysema, lung, airways, air pollution,

angiogenesis, pathology, smooth muscle

1963 - 67 Polytechnic Institute Unified Honors Program; Tau Beta Pi, Eta Kappa Nu, & Sigma XI Honor Societies

1975 - 78 Recipient of Young Investigator Pulmonary Research Grant

1978 - 82 Recipient of NIH Research Career Development Award (HL-00347)

1983 - 90 Editorial Board of American Review of Respiratory Disease

1983 - 96 Editorial Board of Journal of Applied Physiology

1996 ` Elected to the College of Fellows of the American Institute of Medical and Biological Engineering

1999-... Editorial Board of Journal of Applied Physiology

2000 Distinguished Service Award from the American Lung Association of Maryland.

2006 Joseph Rodarte Award for Achievements in Respiratory Medicine and Physiology

2006 - 08 Chair of Respiratory Structure & Function Assembly of the American Thoracic Society.

168. Soutiere SE, Tankersley CG, Mitzner W. Differences in alveolar size in inbred mouse strains. Respir Physiol Neurobiol. 2004 Jun 25;140(3):283-91.

169. Bates J, Irvin C, Brusasco V, Drazen J, Fredberg J, Mitzner W, Pare P, et al. The use and misuse of Penh in animal models of lung disease. Am J Respir Cell Mol Biol. 2004 Sep;31(3):373-4.

170. Groeben H, Meier S. Robert RH, O'Donnell C, Mitzner W, Tankersley C. The effect of leptin on the ventilatory responseto hyperoxia. Exp Lung Res. 2004 Oct-Nov;30(7):559-70.

171. Cox PG, Miller J, Mitzner W, Leff AR. Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations. Eur Respir J. 2004 Oct;24(4):659-63.

173. Brown RH, Wizeman W, Danek C, and Mitzner W. In vivo evaluation of the effectiveness of bronchial thermoplasty with computed tomography. J Appl Physiol 98: 1603-1606, 2005.

Mitzner W. Stresses on pulmonary blood vessels. Am J Physiol Lung Cell Mol Physiol 288: L1-2, 2005

179. Pearse DB, Searcy RM, Mitzner W, Permutt S, and Sylvester JT. Effects of Tidal Volume and Respiratory Frequency on Lung Lymph Flow. J Appl Physiol, 2005.

Brown, R. H., W. Wizeman, et al. (2005). "Effect of bronchial thermoplasty on airway distensibility." Eur Respir J 26(2): 277-82.

180. Glaab T, Ziegert M, Baelder R, Korolewitz R, Braun A, Hohlfeld JM, Mitzner W, Krug N, and Hoymann HG. Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice. Respir Res 6: 139, 2005.

181. Pearse DB, Searcy RM, Mitzner W, Permutt S, and Sylvester JT. Effects of tidal volume and respiratory frequency on lung lymph flow. J Appl Physiol 99: 556-563, 2005.

182. Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, and Biswal S. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med 202: 47-59, 2005.

183. Groeben, H., S. Meier, et al. (2005). "Heritable and pharmacological influences on pauses and apneas in inbred mice during anesthesia and emergence." Exp Lung Res 31(9-10): 839-53.

184. Soutiere, S. E. and W. Mitzner (2006). "Comparison of postnatal lung growth and development between C3H/HeJ and C57BL/6J mice." J Appl Physiol 100(5): 1577-83.

185. Mitzner, W. (2005). "Stresses on pulmonary blood vessels." Am J Physiol Lung Cell Mol Physiol 288(1): L1-2.

186. Wagner EM, Petrache I, Schofield B, and Mitzner W. Pulmonary ischemia induces lung remodeling and angiogenesis. J Appl Physiol 100: 587-593, 2006.

187. Mitzner, W. (2006). "Morphologic quantification of heterogeneous parenchyma." J Appl Physiol 100(4): 1421-2.

188. Mitzner, W. (2006). "Bronchial Thermoplasty in Asthma." Allergology International 55: 225-234.

189. Lande, B. and W. Mitzner (2006). "Analysis of lung parenchyma as a parametric porous medium." J Appl Physiol 101(3): 926-33.