Richard E. Chaisson, M.D., is Professor of Medicine, Epidemiology and International Health and Director of the Johns Hopkins University Center for Tuberculosis Research. From 1988-1998 he was Director of the Johns Hopkins AIDS Service, and co-founded the Johns Hopkins HIV Clinic cohort, an observational study that has been the source of more than 130 scientific publications on the outcomes of HIV disease and its treatment. In 1998 he founded the Center for Tuberculosis Research, a multidisciplinary research and training center with more than $100 million in grants for the study of TB from bench to bedside. Dr. Chaisson's research interests focus on tuberculosis and HIV infection, including global epidemiology and control, prevention, clinical trials, and public health interventions. He is currently principal investigator of 11 research grants, and is principal investigator of the Consortium to Respond Effectively to the AIDS/TB Epidemic (CREATE), an international research consortium funded by the Bill and Melinda Gates Foundation to assess the impact of novel strategies for controlling HIV-related TB. He has published over 300 scientific papers and book chapters.

Tuberculosis, HIV, Infectious Diseases

World Lung Health Award, American Thoracic Society, 2006

Churchyard GJ, Fielding K, Charalambous S, Day JH, Corbett EL, Hayes RJ, Chaisson RE, De Cock KM, Samb B, Grant AD. Efficacy of secondary isoniazid preventive therapy among HIV-infected Southern Africans: time to change policy? AIDS. 2003;17:2063-70.

Benson CA, Williams PL, Currier JS, Holland F, Mahon LF, MacGrego RR, Inderlied CB, Flexner C, Neidg J, Chaisson, RE, Notario GF, Hafner R; AIDS Clinical Trials Grou 223 Protocol Team. A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambuto, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome. Clin Infect Dis. 2003;37:1234-43.

Nuermberger EL, Yoshimatsu T, Tyagi S, O’BRien RJ, Vernon AN, Chaisson RE, Bishai WR, Grosset JH. Moxifloxacin-containing Regimen Greatly Reduces Time to Culture Conversion in Murine Tuberculsosis. Am J Respir Crit Care Med. 2004;169:421-6.

Moore RD, Keruly JC, Chaisson RE. Differences in HIV Disease Progression by Injection Drug Use in HIV-Infected Persons in Care. JAIDS 2004;35:46-51.

Charalambous S, Grant AD, Day JH, Rothwell E, Chaisson RE, Hayes RJ, Churchyard GJ. Feasibility and acceptability of a specialist clinical service for HIV-infected mineworkers in South Africa. AIDS Care 2004;16:47-56.

Nuermberger EL, Yoshimatsu T, Tyagi S, Williams K, Rosenthal I, O'Brien RJ, Vernon AA, Chaisson RE, Bishai WR, Grosset JH. Moxifloxacin-containing Regimens of Reduced Duration Produce a Stable Cure in Murine Tuberculosis. Am J Respir Crit Care Med. 2004, epublished August 11.

Karakousis PC, Moore RD, Chaisson RE. Mycobacterium avium complex in patients with HIV infection in the era of highly active antiretroviral therapy. Lancet Infect Dis. 2004;4:557-65.

Gordin FM, Cohn DL, Matts JP, Chaisson RE, O’Brien RJ. Hepatotoxicity of rifampin and pyrazinamide in the treatment of latent tuberculosis infection in HIV-infected persons: is it different than in HIV-uninfected persons? Clin Infect Dis. 2004;39:561-5.

Boyd S, Thomas-Gosain N, Umbricht A, Tucker M, Leslie J, Chaisson R, Preston K. Gender Differences in Indices of Opioid Dependency and Medical Comorbidity in a Population of Hospitalized HIV-Infected African-Americans. Am J Addict. 2004;13:281-291.

Day JH, Grant AD, Fielding KL, Morris L, Moloi V, Charalambous S, Puren AJ, Chaisson RE, De Cock KM, Hayes RJ, Churchyard GJ. Does Tuberculosis Increase HIV Load? JID 2004;190:1677-84.

Nachega JB, Stein DM, Lehman DA, Hlatshwayo D, Mothopeng R, Chaisson RE, and Karstaedt AS. Adherence to Antiretroviral Therapy in HIV-Infected Adults in Soweto, South Africa. Aids Research And Human Retroviruses 2004;20:1053–1056.

Sulkowski MS, Mehta SH, Chaisson RE, Thomas DL, Moore RD. Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir. AIDS. 2004;18:2277-84.

Mehta SH, Thomas DL, Torbenson M, Brinkley S, Mirel L, Chaisson RE, Moore RD, Sulkowski MS. The effect of antiretroviral therapy on liver disease among adults with HIV and hepatitis C coinfection. Hepatology. 2005;41:123-131.

Wilson D, Nachega JB, Chaisson RE, Maartens G. Diagnostic yield of peripheral lymph node needle-core biopsies in HIV-infected adults with suspected smear-negative tuberculosis. Int J Tuberc Lung Dis 2005:9:220-222.

Nachega JB, Lehaman DA, Hlatshwayo D, Mothopeng R, Chaisson RE, Karstaedt AS. HIV/AIDS and Antiretroviral Treatment Knowledge, Attitudes, Beliefs, and Practices in HIV-infected Adults in Soweto, South Africa. J Acquir Immune Defic Syndr 2005;38:196-201.

Golub JE, Bur S, Cronin WA, Gange S, Sterling TR, Oden B, Baruch N, Comstock GW, Chaisson RE. Impact of empiric antibiotics and chest radiograph on delays in the diagnosis of tuberculosis. Int J Tuberc Lung Dis 2005;9:392-397.

Golub JE, Bur S, Cronin WA, Gange S, Baruch N, Comstock GW, Chaisson RE. Patient and Health care system delays in pulmonary tuberculosis diagnosis in low-incidence state. Int J Tuberc Lung Dis 2005;9:992-998.

Teixeira EG, Menzies D, Comstock GW, Cunha AJ, Kritski AL, Soares LC, Bethlem E, Zanetti G, Ruffino-Netto A, Belo MT, Selig L, Branco MM, Cherri D, Maia S, Marandino R, Luiz RR, Chaisson RE, Trajman A. Latent tuberculosis infection among undergraduate medical students in Rio de Janeiro State, Brazil. Int J Tuberc Lung Dis. 2005;9:841-7.

Grant AD, Charalambous S, Fielding KL, Day JH, Corbett EL, Chaisson RE, De Cock KM, Hayes RJ, Churchyard GJ. Effect of routine isoniazid preventive therapy on tuberculosis incidence among HIV-infected men in South Africa: a novel randomized incremental recruitment study. JAMA. 2005;293:2719-25.

Golub JE, Bur S, Cronin WA, Gange S, Baruch N, Comstock GW, Chaisson RE. Patient and health care system delays in pulmonary tuberculosis diagnosis in a Low-incidence state. Int J Tuberc Lung Dis 2005;9:992-8.

Lucas GM, Griswold M, Gebo KA, Keruly J, Chaisson RE, Moore RD. Illicit Drug Use and HIV-1 Disease Progression: A Longitudinal Study in the Era of Highly Active Antiretroviral Therapy. Am J Epidemiol. 2006 Jan 4;

Mello F, Bastos LG, Soares SL, Rezende VM, Conde MB, Chaisson RE, Kritski AL, Rufino-Netto A and Werneck GL. Predicting smear negative pulmonary tuberculosis with classification trees and logistic regression: a crass-sectional study. BMC Public Health 2006;6:43.

Dowdy DW, Chaisson RE, Moulton LH, Dorman SE. The potential impact of enhanced diagnostic techniques for tuberculosis driven by HIV: a mathematic model. AIDS 2006;751-762.

Wilson D, Nachega J, Morroni C, Chaisson R, Maartens G. Diagnosing smear-negative tuberculosis using case definitions and treatment response in HIV-infected adults. Int J Tuberc Lung Dis. 2006 Jan;10(1):31-8.

Golub JE, Bur S, Cronin WA, Gange S, Baruch N, Comstock GW, Chaisson RE. Delayed tuberculosis diagnosis and tuberculosis transmission. Int J Tuberc Lung Dis. 2006 Jan;10(1):24-30.

Schechter M, Zajdenverg R, Falco G, Barnes GL, Faulhaber JC, Coberly JS, Moore RD, Chaisson RE. Weekly Rifapentine/Isoniazid or Daily Rifampin/Pyrazinamide for Latent Tuberculosis in Household Contacts. Am J Respir Crit Care Med 2006;178:922-6.

Kali PB, Gray GE, Violari A, Chaisson RE, McIntyre JA, Martinson NA. Combining PMTCT With Active Case Finding for Tuberculosis. J Acquir Immune Defic Syndr. 2006 Jul;42(3):379-81.

Burman WJ, Goldberg S, Johnson JL, Muzanye G, Engle M, Mosher AW, Choudhri S, Daley CL, Munsiff SS, Zhao Z, Vernon A, Chaisson RE. Moxifloxacin versus Ethambutol in the First Two Months of Treatment for Pulmonary Tuberculosis.Am J Respir Crit Care Med. 2006 Aug 1;174(3):331-8.

Soares ECC, Pacheco AGF, Mello FCQ, Durovni B, Chaisson RE, Cavalcante SC. Imporvements in tereatment success rates with directly observed therapy in Rio de Janeiro City. Int J Tuberc Lung Dis 2006;10:690-695.

Nachega JB, Hislop M, Dowdy DW, Lo M, Omer SB, Regensberg L, Chaisson RE, Maartens G. Adherence to Highly Active Antiretroviral Therapy Assessed by Pharmacy Claims Predicts Survival in HIV-infected South African Adults. J Acquir Immune Defic Syndr. 2006;43:78-84.

Soares EC, Pacheco AG, Mello FC, Durovni B, Chaisson RE, Cavalcante SC. Improvements in treatment success rates with directly observed therapy in Rio de Janeiro City. Int J Tuberc Lung Dis. 2006 Jun;10(6):690-5.

Sterling TR, Zhao Z, Khan A, Chaisson RE, Schluger N, Mangura B, Weiner M, Vernon A; Tuberculosis Trials Consortium. Mortality in a large tuberculosis treatment trial: modifiable and non-modifiable risk factors. Int J Tuberc Lung Dis. 2006;10:542-9.