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Faculty
Sungano Mharakurwa
Research Associate
Academic Degrees
DPHIL, MSc
Departmental Affiliation
Molecular Microbiology and Immunology
Research and Professional Experience

Investigating public health strategies for delaying or minimizing the evolution of Plasmodium falciparum resistance to antimalarial drugs. Currently examining the field dynamics and determinants of drug-resistant P. falciparum alleles in human and vector phases in order to identify potential targets for containment approaches. Previous work included the relationship of Plasmodium falciparum transmission control on levels of multigenic drug resistance. Parallel studies explore the development of non-invasive methods for the detection of P. falciparum malaria using human saliva and urine samples.

Keywords

Malaria, Plasmodium falciparum, transmission, drug resistance, detection, saliva, evolution, control

Selected Publications

Rouse, P., Mkulama A.P., Thuma P.E., Mharakurwa S. (2008) Distinction of Plasmodium falciparum recrudescence and re-infection by MSP2 genotyping: a caution on unstandardized criteria Malaria Journal 7: 185.

Mkulama M.A.P, Chishimba S., Sikalima J., Rouse P., Thuma P.E., Mharakurwa S. (2008) Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia Malaria Journal 7: 87.

Chishimba S., Kamanga A., Sikalima J., Clennon J., Mharakurwa S., Shiff C.J. (2008) Urinary schistosomiasis scourge among rural school children in Chitongo area, Southern Zambia. Zambia Medical Journal 34 (4) 141-145.

Kent R.J., Mharakurwa S., Norris D.E. (2007) Spatial and temporal genetic structure of Anopheles arabiensis in Southern Zambia over consecutive wet and drought years American Journal of Tropical Medicine& Hygiene 77 316-323.

Kent R. J., Mharakurwa S., Hamapumbu H., Norris D.E. (2007) Recognition of a novel melanotic mutant in a field population of Culex pipiens quinquefasciatus Say in Southern Zambia. Journal of the American Mosquito Control Association 23 71-75.

Kent R.J., Thuma P., Mharakurwa S., Norris D.E. (2007) Seasonality, blood feeding behavior and transmission of Plasmodium falciparum by Anopheles arabiensis following an extended drought in Southern Zambia American Journal of Tropical Medicine& Hygiene 76 267-274

Mharakurwa S., Simoloka C., Thuma P.E., Shiff C.J. and Sullivan D.J. (2006) PCR detection of Plasmodium falciparum in human urine and saliva samples Malaria Journal 5: 103

Kent R.J., Coetzee M., Mharakurwa S. and Norris D.E. (2006) Feeding and indoor resting behaviour of the mosquito Anopheles longipalpis in an area of hyperendemic malaria transmission in Southern Zambia Medical and Veterinary Entomology 20 (4) 459-63.

Mharakurwa S. (2004) Plasmodium falciparum transmission rate and the selection for drug resistance: a vexed association or a key to successful control? International Journal for Parasitology 34 (13-14) 1483-1487.

Mharakurwa S., Mutambu S.L., Mudyiradima R., Chimbadzwa T., Chandiwana S.K. and Day K.P. (2004) Association of house spraying with suppressed levels of drug resistance in Zimbabwe. Malaria Journal 3 (1) 35.

Anderson T.J.C., Haubold B., Williams J.T., Estrada-Franco J.G., Mollinedo R., Brockarie M., Mokili J., Mharakurwa S., French N., Whitworth J., Velez I. D., Brockman A.H., Nosten F., Ferreira M. And Day K.P. (2000) Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Molecular Biology and Evolution 17 (10) 1467-1482.

Murahwa-F.C., Mharakurwa S., Mutambu S.L., Rangarira R. and Musana B.J. (1999) Diagnostic performance of two antigen capture tests for the diagnosis of Plasmodium falciparum malaria in Zimbabwe. Central African Journal of Medicine 45(4): 97-100.

Mharakurwa S., Rangarira R., Murahwa F.C., and Chandiwana S.K. (1998) Status of chloroquine efficacy against falciparum malaria in Mola area of Kariba district, Zimbabwe Annals of Tropical Medicine and Parasitology 92 655-661.

Mharakurwa S., Manyame B., and Shiff C.J. (1997) Trial of the Parasight®-F test for malaria diagnosis in the primary health care system, Zimbabwe. Tropical Medicine & International Health 2 (6) 544-550.

Mharakurwa S. and Shiff C.J. (1997) Post-treatment sensitivity studies with the ParaSight-F test for malaria diagnosis in Zimbabwe. Acta Tropica 66 61-67.

Vundule C. and Mharakurwa S. (1996) Knowledge, practices, and perceptions about malaria in rural communities of Zimbabwe: Relevance to malaria control. Bulletin of the World Health Organization 74 (1) 55-60.

Mharakurwa S. (1995) A case of dual chloroquine and halofantrine treatment failure in Zimbabwe. Central African Journal of Medicine 41 327.

Mharakurwa S., Carucci D.J. and Warhurst D.C. (1994) Dihydrofolate-reductase mutations in Plasmodium falciparum from Zimbabwe. Transactions of the Royal Society of Tropical Medicine and Hygiene 88 376.

Mharakurwa S. and Mugochi T. (1994) Response of chloroquine-resistant falciparum malaria to sulfadoxine/pyrimethamine in Gokwe area of Zimbabwe. Central African Journal of Medicine 40 53-56.

Mharakurwa S. and Mugochi T. (1994) Chloroquine-resistant falciparum malaria in an area of rising endemicity in Zimbabwe. Journal of Tropical Medicine and Hygiene 97 39-45.

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