NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Shin S., Wakabayashi N., Misra V., Biswal S., Lee G.H., Agoston E.S., Yamamoto M., Kensler T.W. Mol. Cell Biol. 27, 7188-7197, (2007)
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Kensler TW. Wakabayashi N. and Biswal S. Annu. Rev. Pharmacol. Toxicol. 47, 89-116, (2007)
Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Osburn W.O., Wakabayashi N., Misra V., Nilles T., Biswal S., Trush M.A. and Kensler T.W. Arch. Biochem. Biophys. 454, 7-15, (2006)
Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-D12,14-Prostaglandin J2 is attenuated by alkenal/one oxidoreductase. Yu X., Egner PA, Wakabayashi J., Wakabayashi N., Yamamoto M. and Kensler T. W. J Biol Chem. 281, 26245-26252, (2006)
Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein. Dinkova-Kostova AT, Holtzclaw WD, Wakabayashi N. Biochemistry 44. :6889-6899. (2005)
Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Kwak MK, Wakabayashi N., Kensler T.W. Mutat Res. 555, 133-148, (2004)
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Kang MI, Kobayashi A, Wakabayashi N, Kim SG, Yamamoto M. Proc Natl Acad Sci USA. 101, 2046-2051. (2004)
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers. Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang ML, Kobayashi A, Yamamoto M, Kensler T.W, Talalay P. Proc Natl Acad Sci USA 101, 2040-2045. (2004)
Chemoprevention by 1,2-dithiole-3-thiones through induction of NQO1 and other phase 2 enzymes. Kwak MK, Ramos-Gomez M, Wakabayashi N, Kensler TW. Methods Enzymol. 382, 414-423 (2004)
p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis. Habu T, Wakabayashi N, Yoshida K, Yomogida K, Nishimune Y, Morita T. Carcinogenesis. 25, 889-893, (2004)
Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway. Kwak MK., Wakabayashi N., Greenlaw J.L., Yamamoto M., Kensler T.W. Mol Cell Biol. 23, 8786-8794, (2003)
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Wakabayashi, N, Itoh K., Wakabayashi J., Motohashi H., Noda S., Takahashi S., Imakado S., Kotsuji T., Otsuka F., Roop D.R, Harada T., Engel J.D., Yamamoto M. Nat Genet. 35, 238-245, (2003)
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Itoh K., Wakabayashi N., Katoh Y., O?Cornor T. and Yamamoto M. Genes Cells 8, 379-391, (2003)
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: Identification of novel gene clusters for cell survival. Kwak M.K., Wakabayashi N., Itoh K., Motohashi H., Yamamoto M., Kensler T.W. J Biol Chem. 278, 8135-8145, (2003)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., Itoh K., Wakabayashi N., Katoh Y., Yamamoto M., Talalay P. Proc Natl Acad Sci USA. 99, 11908-11913, (2002)
Induction of instability of p34 (cdc2) expression by treatment with cisplatin (CDDP) in mouse teratocarcinoma F9 cells. Doi T., Morita T. Wakabayashi N., Sumi T., Iwai S., Amekawa S., Sakuda M., Nishimune Y. Cancer Lett. 176, 75-80, (2002)
A Novel Cis-Acting Element Regulates HES-1 Gene Expression in P19 Embryonal Carcinoma Cells Treated with Retinoic Acid Wakabayashi N., Kageyama R., Habu T., Doi T., Morita T., Nozaki M., Yamamoto M. and Nishimune Y. J.Biochem. 128, 1087-1095, (2000)
Regulatory mechanisms of cellular response to oxidative stress. Itoh K., Ishii T., Wakabayashi N., Yamamoto M. Free Radic Res. 33, 319-324, (1999)
The cDNA cloning and transient expression of an ovary-specific 17b-hydroxysteroid dehydrogenase of chickens. Wajima Y., Furusawa T., Kawauchi S., Wakabayashi N., Nakabayashi O., Nishimori K. and Mizuno S. Gene 233, 75-82, (1999)
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J. D. and Yamamoto M. Genes & Dev. 13, 76-86 (1999).
Molecular cloning and characterization of Meichroacidin (Male Meiotic Metaphase Chromosome-Acidic Protein ). Tsuchida J., Nishina Y., Wakabayashi N., Nozaki M., Sakai Y. and Nishimune Y. Dev. Biol. 197, 67-76 (1998).
Isolation and expression of a chicken DNA methyltransferase cDNA. Tajima S., Tsuda H., Wakabayashi N., Asano A., Mizuno S. and Nishimori K. J. Biochem. 117, 1050-1057, (1995).
