Major Research Projects:

Effect of chronic Mn exposure on cognition and the central nervous system

Effect of Pb2+ exposure on cognition and the developing central nervous system

Development and application of biomarkers to assess central nervous system injury

Environmental Health Sciences; Neurotoxicology; lead neurotoxicity/NMDA receptor/learning and memory; manganese neurotoxicity; biomarkers of brain injury/Parkinson's disease; brain imaging/positron emission tomography/magnetic resonance imaging and spectroscopy; Peripheral Benzodiazepine Receptor; Translocator Protein 18kd

-Society for Neuroscience

-Society of Toxicology & Neurotoxicology Specialty Section

Guilarte TR, Burton NC, McGlothan JL, Verina T, Zhou Y, Alexander M, Pham L, Griswold M, Wong DF, Syversen T, Schneider JS. (2008) Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): Implications to manganese-induced parkinsonism. J Neurochem. 107(5):1236-47.

McGlothan JL, Karcz-Kubicha M, Guilarte TR. (2008) Developmental lead exposure impairs extinction of conditioned fear in young adult rats. Neurotoxicology 29(6):1127-30.

Guilarte TR, Hammoud DA, McGlothan JL, Caffo BS, Foss CA, Kozikowski AP, Pomper MG. (2008) Dysregulation of Glutamate Carboxypeptidase II in Psychiatric Disease. Schizophrenia Research 99(1-3):324-32.

Chen M-K, Kuwabara H, Zhou Y, Adams RJ, Brasic JR, McGlothan JL, Verina T, Burton NC, Alexander M, Kumar A, Wong DF, Guilarte TR. (2008) VMAT-2 and dopamine neuron loss in a non-human primate model of Parkinson’s disease. J Neurochem 105(2):78-90.

Guilarte TR, McGlothan JL, Degaonkar M, Chen MK, Barker PB, Syversen T, Schneider JS. (2006) Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study. Toxicol Sci. 94(2):351-8.

Guilarte TR, Chen MK, McGlothan JL, Verina T, Wong DF, Zhou Y, Alexander M, Rohde CA, Syversen T, Decamp E, Koser AJ, Fritz S, Gonczi H, Anderson DW, Schneider JS. (2006) Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Exp Neurol. 202(2):381-90.

Toscano CD, McGlothan JL, Guilarte TR. (2006) Experience-dependent regulation of zif268 gene expression and spatial learning. Exp. Neurol. 200(1):209-15.

Chen MK, Lee JS, McGlothan JL, Furukawa E, Adams RJ, Alexander M, Wong DF, Guilarte TR. (2006) Acute manganese administration alters dopamine transporter levels in the non-human primate striatum. Neurotoxicology 27(2):229-36.

Guilarte TR, McGlothan JL, Foss CA, Zhou J, Heston WD, Kozikowski AP, Pomper MG. (2005) Glutamate carboxypeptidase II levels in rodent brain using [125I]DCIT quantitative autoradiography. Neurosci Lett. 387(3):141-4.

Guilarte TR, Nihei MK, McGlothan JL, and Howard AS. (2003) Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticity. Neuroscience 122(2):499-513.

Toscano CD, McGlothan JL, and Guilarte TR. (2003) Lead exposure alters cyclic-AMP response element binding protein phosphorylation and binding activity in the developing rat brain. Dev. Brain Res. 145(2):219-28.

Guilarte TR and McGlothan JL. (2003) Selective decrease in NR1 subunit splice variant mRNA in the hippocampus of Pb2+-exposed rats: implications for synaptic targeting and cell surface expression of NMDAR complexes. Mol. Brain Res. 113(1-2):37-43.

Guilarte TR, Toscano CD, McGlothan JL, and Weaver SA. (2003) Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure. Ann. Neurol. 53(1):50-6.

Toscano CD, Hashemzadeh-Gargari H, McGlothan JL, and Guilarte TR. (2002) Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. Dev. Brain Res. 139(2):217-26.

Nihei MK, McGlothan JL, Toscano CD, Guilarte TR. (2001) Low level Pb(2+) exposure affects hippocampal protein kinase C gamma gene and protein expression in rats. Neurosci. Lett. 298(3):212-6.

Nihei MK, Desmond NL, McGlothan JL, Kuhlmann AC, and Guilarte TR. (2000) N-methyl-D-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning. Neuroscience 99(2):233-42.

Guilarte TR, McGlothan JL and Nihei MK. (2000) Hippocampal expression of N-methyl-D-aspartate receptor (NMDAR1) subunit splice variant mRNA is altered by developmental exposure to Pb2+. Molec. Brain Res. 76:299-305.

Guilarte TR and McGlothan JL. (1998) Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure. Brain Res. 790:98-107.

Kuhlmann AC, McGlothan JL and Guilarte TR. (1997) Developmental lead exposure causes spatial learning deficits in adult rats. Neurosci. Lett. 233:101-4.