Tuberculosis. Our participation in research concerns pulmonary tuberculosis produced by aerosolized virulent bacilli in the rabbit model: Prevention, with new and old vaccines, and therapy with drugs to prevent liquefaction and cavity formation in this disease. This research involves a thorough gross- and histopathological study of the effects of the vaccines and drugs on this disease.

tuberculosis; BCG; sulfur mustard; cytokines, adhesion molecules; allergic dermatitis; macrophages and lymphocytes; cell mediated immunity (CMI); delayed-type hypersensitivity DTH).

Delta Omega Public Health Honorary Society, Alpha Chapter (elected 1983);

Society for Leukocyte Biology, Honorary Life Membership (awarded 1984).

Special guest lecture, Inflammation Society of Japan, Tokyo, July 1990

School of Hygiene Dean's Lecture, 1/10/91

JHU Immunology Council lecture, 10/8/92

The Pathogenesis of Tuberculosis: A Symposium in Honor of Arthur M. Dannenberg, Jr., at JHSPH 10/6/2004.

Listed in: American Men and Women of Science; Who's Who.

1. Dannenberg AM Jr. (2006) Pathogenesis of Human Pulmonary Tuberculosis: Insights from the Rabbit Model. ASM Press, Washington, DC.

2. Manabe YC, Dannenberg AM Jr. (2006) Pathophysiology: Basic aspects. I. Pathogenesis of tuberculosis. II. Immunology of tuberculosis. In Schlossberg D, ed. Tuberculosis and Nontuberculous Mycobacterial Infections, Fifth Edition. McGraw-Hill, New York. pp. 18-51.

3. Dorman SE, Hatem CL, Tyagi S, Aird K, Lopez-Molina J, Pitt MLM, Zook BC, Dannenberg AM Jr, Bishai WR, Manabe YC. (2004) Susceptibility to tuberculosis: Clues from studies with inbred and outbread New Zealand White rabbits. Infect Immun 72: 1700-1705.

4. Dannenberg AM Jr. (2003) Macrophage turnover, division and activation within developing, peak and “healed” tuberculous lesions produced in rabbits by BCG. Tuberculosis 83: 251-260.

5. Manabe YC, Dannenberg AM Jr, Tyagi S, Hatem CL, Yoder M, Woolwine SC, Zook BC, Pitt MLM, Bishai WR. (2003) Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis. Infect Immun 71: 6004-6011.

6. Dannenberg AM Jr, Collins FM. (2001) Progressive pulmonary tuberculosis is not due to increasing numbers of viable bacilli in rabbits, mice and guinea pigs, but is due to a continuous host response to mycobacterial products. Tuberculosis 81: 229-242.

7. Dannenberg AM Jr. (2001) Pathogenesis of pulmonary Mycobacterium bovis infection: Basic principles established by the rabbit model. In Third International Conference on Mycobacterium bovis. Cambridge, U.K., July 13-16, 2000. Tuberculosis 81: 87-96.

8. Shigenaga T, Dannenberg AM Jr, Lowrie DB, Said W, Urist MJ, Abbey H.Schofield BH, Mounts P, Sugisaki K. (2001) Immune responses in tuberculosis: Antibodies and CD4/CD8 lymphocytes with vascular adhesion molecules and cytokines (chemokines) cause a rapid antigen-specific cell infiltration at sites of bacillus Calmette-Guérin reinfection. Immunol 102: 466-479.

9. Manabe YC, Dannenberg AM Jr, Bishai WR. (2000 ) What we can learn from the Mycobacterium tuberculosis genome sequencing projects. Int J Tuberc Lung Dis 4: S18-S23.

10. Dannenberg AM Jr, Bishai WR, Parrish N, Ruiz R, Johnson W, Zook BC, Boles JW, Pitt MLM. (2000) Efficacies of BCG and vole bacillus (Mycobacterium microti) vaccines in preventing clinically apparent pulmonary tuberculosis in rabbits: a preliminary report. Vaccine 19: 796-800.

11. Bishai WR, Dannenberg AM Jr, Parrish N, Ruiz R, Chen P, Zook BC, Johnson W, Boles, JW, Pitt MLM. (1999 ) Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie’s pulmonary tubercle count method. Infect Immun 67: 4931-4934.

12. Dannenberg AM Jr. (1999) Pathophysiology: Basic aspects. I. Pathogenesis of tuberculosis. II. Immunology of tuberculosis. In Schlossberg D, ed. Tuberculosis and Nontuberculous Mycobacterial Infections, Fourth Edition. W.B. Saunders Co, Philadelphia. pp. 17-47.

13. Dannenberg AM Jr, Tomashefski JF Jr. (1998) Pathogenesis of pulmonary tuberculosis. In Fishman’s Pulmonary Diseases and Disorders, Third Edition, Vol. 2. Fishman AP, Editor-in-Chief. McGraw-Hill Co., Inc., New York. pp. 2447-2471.

14. Dannenberg AM Jr. (1998) Lurie’s tubercle-count method to test TB vaccine efficiency in rabbits. Frontiers in Bioscience 3: c27-33. Available on the Internet: http://www.bioscience.org/1998/v3/c/dannenbe/list.htm

15. Converse PJ, Dannenberg AM Jr, Shigenaga T, McMurray DN, Phalen SW, Stanford JL, Rook GAW, Koru-Sengul T, Abbey H, Estep JE, Pitt MLM. (1998) Pulmonary bovine type tuberculosis in rabbits: Bacillary virulence, inhaled dose effects, tuberculin sensitivity, and Mycobacterium vaccae immunotherapy. Clin Diag Lab Immunol 5: 871-881.

16. Sugisaki K, Dannenberg AM Jr, Abe Y, Tsuruta J, Su W-J, Said W, Feng L, Yoshimura T, Converse PJ, Mounts P. (1998) Nonspecific and immune-specific up-regulation cytokines in rabbit dermal tuberculous (BCG) lesions. J Leukoc Biol 63: 440-450.

17. Tanaka F, Dannenberg AM Jr, Higuchi K, Nakamura M, Pula PJ, Hugli TE, DiScipio RG, Kreutzer DL. (1997) Chemotactic factors are continuously released by cultured intact developing and healing skin lesions produced in rabbits by sulfur mustard. Inflammation 21: 251-267.

18. Converse PJ, Dannenberg AM Jr, Estep JE, Sugisaki K, Abe Y, Schofield BH, Pitt MLM. (1996) Cavitary tuberculosis produced in rabbits by aerosolized virulent tubercle bacilli. Infect Immun 64: 4776-4787.

19. McMurray DN, Collins FM, Dannenberg AM Jr, Smith DW. (1996) Pathogenesis of experimental tuberculosis in animal models. In Shinnick TM, ed. Tuberculosis. Springer-Verlag, Berlin. pp. 157-179.

20. Tsuruta J, Sugisaki K, Dannenberg AM Jr, Yoshimura T, Abe Y, Mounts P. (1996) The cytokines NAP-1 (IL-8), MCP-1, IL-1 beta, and GRO in rabbit inflammatory skin lesions produced by the chemical irritant sulfur mustard. Inflammation 20: 293-318.