My current research focuses on clinical trials of vaccines for potential pandemic influenza strains. At the Center for Immunization Research, we conduct phase I and II clinical trials of vaccine candidates for many diverse pathogens. As part of the Pandemic Influenza Preparedness and Response Plan, we plan and execute phase I trials evaluating the safety and immunogenicity of a number of influenza vaccine candidates targeting strains with pandemic potential. Also, as I am trained in Infectious Diseases and parasitology, I retain an interest in tropical medicine and international health.

International Health, Avian Influenza, Pandemic Influenza, Vaccines, Parasitology

Talaat, K. R., Rothman, J. A., Cohen, J. I., Santi, M., Rorke-Adams, L. B., Choi, J. K., Guzman, M., Zimmerman, R., Nallasamy, S., Brucker, A., Quezado, M., Pittaluga, S., Patronas, N. J., Klion, A. D. and Nichols, K. E. Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein Barr virus infection. Pediatric Blood and Cancer, in press.

Talaat, K. R., Karron, R. A., Callahan, K. A., Luke, C., DiLorenzo, S., Chen, G., Lamirande, E., Jin, H., Coelingh, K., Kemble, G., and Subbarao, K. A live attenuated H7N3 influenza virus vaccine is well-tolerated and immunogenic in healthy adults. Vaccine 2009; 27: 3744-3753.

Talaat, K. R., Kumarasamy, N, Swaminathan, S., Gopinath, R., and Nutman, T. B. Filarial/HIV coinfection in urban South India. Am J Trop Med Hyg 2008; 79(4):558-60.

Mitre, E., Talaat, K. R., Sperling, M.R. and Nash, T.E. Methotrexate as a Corticosteroid-sparing Agent in Complicated Neurocysticercosis. Clin Infect Dis 2007; 44(4): 549-53.

Talaat, K. R. and Nutman, T. B. Pneumonia: parasitic. In Laurent, G. J. and Shapiro, S. D. (ed) Encyclopedia of Respiratory Medicine Oxford: Elsevier, 2005.

Talaat, K. R., Bonawitz, R. E., Domenech, P. and Nutman, T. B. Pre-exposure to live Brugia malayi microfilariae alters the innate response of dendritic cells to Mycobacterium tuberculosis. J Infect Dis 2006; 193: 196-204.

Talaat, K. R. and Nutman, T. B.: Parasitic Diseases In Murray J.F. and Nadel J.A. (ed) Textbook of Respiratory Medicine 4th edition. Philadelphia: W.B. Saunders Company, 2005.