My main research interests is aging in the context of human immunodeficiency virus (HIV) infection. Non-AIDS related aging outcomes of interest include cardiovascular disease, diabetes, end-stage renal disease, cancer, liver disease, and influenza vaccination and infection. AIDS-related aging outcomes include immunologic and virologic response to highly active antiretroviral therapy (HAART). Research objectives include 1) determining the predictive accuracy of HIV biomarkers for disease progression in women aging with HIV infection; 2) determining the relationship of biomarkers of cardiovascular disease with HIV infection; 3) determining the relationship of immune markers on the development of metabolic diseases in HIV-infected individuals; 4) determining the effectiveness of the influenza vaccination in HIV-infected individuals; 5) response to HAART by decade of age and initial HAART regimen; and 6) identifying appropriate comparison groups for non-AIDS-related comorbidities in aging, HIV-infected adults.

Other research interests include sex-based differences in HIV viral load, health disparities in special populations, and epidemiologic methodology issues in prediction modeling and causal inference of treatment effects. I investigate these topics using nested study designs in the MACS, WIHS, ALIVE and NA-ACCORD cohorts of HIV-infected and -uninfected individuals.

HIV/AIDS, aging, influenza, vaccine, health disparities, prediction, causal inference

The Dorothy and Arthur Samet Award for outstanding service to the department and community, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 2007

Althoff KN, Karpati A, Hero J, Matte TD. Secular changes in mortality disparities in New York City: A reexamination. Journal of Urban Health. 2009;86(5):729-44.

Althoff KN, Paul P, Burke AE, Viscidi R, Sangaramoorthy M, Gravitt PE. Correlates of cervicovaginal, human papillomavirus detection in perimenopausal women. Journal of Women’s Health. 2009;18(9):1341-1346.

Mansoor A, Althoff KN, Gange S, Anastos K, DeHovitz J, Minkoff H, Kaplan RC, Holman S, Lazar J. Elevated NT-pro-BNP levels are associated with comorbidities among HIV infected women. AIDS Research and Human Retroviruses. 2009;25(10):997-1004.