I am a pediatrician with subspecialty training in infectious diseases, and have worked in Ethiopia, Kenya, South Africa and Zambia. My broad research interests are the epidemiology and control of childhood infections in developing countries. My primary research interest is in understanding the impact of the HIV-1 epidemic on measles control and eradication. We collaborate with investigators in Lusaka, Zambia and the London School of Hygiene and Tropical Medicine to study the clinical, epidemiologic and immunologic interactions between measles virus and HIV-1 in hospitalized children, and the impact of HIV-1 infection on immune responses to measles vaccination in Zambian children. Current areas of research are understanding how immune reconstitution following antiretroviral therapy impacts humoral and cellular immune responses to measles vaccine.

Additional research projects include child health in complex emergencies, the effectiveness of the care of HIV-1-infected children in rural Zambia, malaria transmission dynamics and control in southern Zambia, and the impact of maternal schistosomiasis on offspring immune responses in a murine model.

infectious diseases, epidemiology, child health, pediatrics, measles, HIV, malaria, complex emergencies, Zambia

Wyeth-Lederle Vaccines and Pediatrics Young Investigator Award in Vaccine Development presented by the Infectious Disease Society of America (1999-2001)

The Gustave J. Martin Innovative Research Fund Fellow, Johns Hopkins University Bloomberg School of Public Health Faculty Innovation Fund (2001)

Advising, Mentoring and Teaching Recognition Award. Student Assembly Honors & Awards Committee. Bloomberg School of Public Health (2007-2008).

van Dijk JH, Sutcliffe CG, Munsanje B, Hamangaba F, Thuma PE, Moss WJ. Barriers to the care of HIV-infected children in rural Zambia. BMC Infect Dis 2009;9:169.

Nair N, Moss WJ, Scott S, Mugala N, Ndhlovu ZM, Ryon JJ, Monze M, Quinn TC, Cousens S, Cutts F, Griffin DE. HIV-1 infection of Zambian children impairs development and avidity maturation of measles virus-specific IgG following vaccination and infection. J Infect Dis 2009;200:1031-8.

Chen SY, Moss WJ, Pipkin SS, McFarland W. A novel use of AIDS surveillance data to assess the impact of initial treatment regimen on survival. Int J STD AIDS 2009;20:330-5.

Moss WJ and Scott S. Module 7: Measles. The Immunological Basis for Immunization Series. World Health Organization. Department of Immunization, Vaccines and Biologicals, Geneva, 2009.

Lowther SA, Curriero FC, Kalish B, Shields TM, Monze M, Moss WJ. Population immunity to measles virus and the effect of HIV-1 infection after a mass measles vaccination campaign in Lusaka, Zambia: a cross-sectional survey. Lancet 2009;373:1025-32.

Lowther SA, Curriero FC, Shields T, Ahmed S, Monze M, Moss WJ. Feasibility of satellite image-based sampling for a health survey among urban townships of Lusaka, Zambia. Trop Med Int Health 2009;14:70-8.

Moss WJ. Measles control and the prospect of eradication. Curr Top Microbiol Immunol 2009;330:173-189.

Moss WJ, Scott S, Ndhlovu Z, Hauer D, Sutcliffe CG, Mugala N, Monze M, Cousens S, Cutts FT, Quinn TC, Griffin DE. Suppression of HIV-1 viral load during acute measles. Pediatr Infect Dis J 2009;28:63-65.

World Health Organization. Manual for the Health Care of Children in Humanitarian Emergencies. Muhe L, Gayer M, Moss WJ, Eds. 2008. World Health Organization, Geneva.

Sutcliffe CG, Scott S, Mugala N, Ndhlovu Z, Monze M, Quinn TC, Cousens S, Griffin DE, Moss WJ. Survival from nine months of age among HIV-1-infected and uninfected Zambian children prior to the availability of antiretroviral therapy. Clin Infect Dis 2008;47:837-44.

Sutcliffe CG, van Dijk JH, Bolton C, Persaud D, Moss WJ. The effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa: a review. Lancet Infect Dis 2008;8:477-89.

Morris SK, Moss WJ, Halsey N. Global Haemophilus influenzae Type b conjugate vaccine use and effectiveness. Lancet Infect Dis 2008; 8:435-43.

Garcia M, Yu XF, Griffin DE, Moss WJ. Measles virus inhibits HIV-1 reverse transcription and productive replication by blocking cell cycle progression of CD4+ T-lymphocytes. J Gen Virol 2008;89:984-993.

Scott S, Mossong J, Moss WJ, Cutts FT, Cousens S. Predicted impact of the HIV-1 epidemic on measles in developing countries: results from a dynamic age-structured model. Int J Epidemiol 2008; 37:356-67.

Moss WJ, Fisher C, Scott S, Monze M, Ryon JJ, Quinn TC, Griffin DE, Cutts FT. HIV-1 infection is a risk factor for mortality in hospitalized Zambian children with measles. Clin Infect Infect 2008;46:523-527.

Scott S, Moss WJ, Cousens S, Beeler JA, Audet SA, Mugala N, Quinn TC, Griffin DE, Cutts FT. The influence of HIV-1 exposure and infection on levels of passively-acquired antibodies to measles virus in Zambian infants. Clin Infect Dis 2007;45:1417-24.

Moss WJ, Scott S, Mugala N, Ndhlovu Z, Beeler J, Audet S, Ngala M, Mwangala S, Nkonga-Mwangilwa C, Ryon JR, Monze M, Kasolo F, Quinn TC, Cousens S, Griffin DE, Cutts FT. Immunogenicity of standard-titre measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. J Infect Dis 2007;196;347-55.

Riddell MA, Moss WJ, Hauer D, Monze M, Griffin DE. Slow clearance of measles virus RNA after acute infection. JClin Virol 2007;39:312-7.

Zilliox MJ, Moss WJ, Griffin DE. Gene expression changes in peripheral blood mononuclear cells during measles. Clin Vaccine Immunol 2007;14:918-23.

Ota MO, Ndhlovu Z, Oh SK, Berzofsky JA, Moss WJ, Griffin DE. The measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination. J Infect Dis 2007;195:1799-1807.

Moss WJ, Griffin DE. Global measles elimination. Nat Rev Micro 2006;4:900-8.

Moss WJ, Ramakrishnan M, Storms D, Henderson Siegle A, Weiss WH, Lejnev I, Muhe L. Child health in complex emergencies. Bull World Health Org 2006;84:58-64.

Bobat R, Coovadia H, Stephen C, Naidoo KL, McKerrow N, Black RE, Moss WJ.. Safety and efficacy of zinc supplementation in HIV-infected children: randomized, double-blind, placebo-controlled trial. Lancet 2005;366:1862-7.