I am interested in the use of the latest technology available, including HPLC-ECD and HPLC-MS/MS to investigate oxidative stress initially in cell culture and animal models. Studies in this area are prompted by the notion, which has been considered since the early 1950’s that reactive oxygen species (ROS) might be the causative agent in human pathologies. Endpoint measurements include lipid peroxidation, antioxidant status, as well as oxidative DNA damage. Successful results from animal studies will be translated into community-based nutritional supplementation with vitamins and antioxidants looking at the reduction of risk of cancer.

Environmental Health Sciences, Oxidative stress, Free radical metabolism, oxidative DNA damage, DNA repair, antioxidant defense and cancer.