My research interests include the epidemiology of vaccine-preventable infectious diseases and the methodologic issues pertaining to the design, conduct and analysis of epidemiologic studies and clinical trials. Currently I serve as the Director of Epidemiology for the Pneumococcal Accelerated Development and Introduction Plan (PneumoADIP). Current projects include determining the causes of pneumonia in settings representative of developing countries to guide the development of new pneumonia vaccines and treatment algorithms for 2015 onwards, estimating the burden and serotype distribution of pneumococcal and meningococcal disease among children and adults, measuring the impact on disease burden of pneumococcal conjugate vaccine use in Kenya and The Gambia, and evaluating the value of antigen-based diagnostic tests in blood to improve sensitivity of pneumococcal detection in pneumonia patients.

vaccines, international health, S. Pneumoniae, H. influenzae, pneumonia, vaccine preventable diseases, epidemiology, clinical trials

National Institutes of Health Merit Award (1999,1991)

Food and Drug Administration Commissioner’s Special Citation Group Award (1997)

U.S. DHHS Secretary’s Group Award for Distinguished Service (1996)

U.S. DHHS Special Achievement Award (1995,1991)

Deloria-Knoll M, E Henkle, E Lee, N McCall, J Moisi, J Watt, K O’Brien and the Hib and Pneumococcal Global Burden of Disease Working Group. Global literature review of Haemophilus influenzae type b and Streptococcus pneumoniae invasive disease among children less than five years of age, 1980-2005. WHO report. 2009; WHO/IVB/09.02. http://whqlibdoc.who.int/hq/2009/WHO_IVB_09.02_eng.pdf

Deloria Knoll M, Moïsi JC, Muhib FB, Wonodi CB, Lee EH, Grant L, Gilani Z, O’Brien KL, Cherian T, Levine OS and the PneumoADIP-Sponsored Surveillance Investigators. Standardizing Surveillance for Pneumococcal Disease. Clin Infect Dis. 2009;48 Suppl 2:S37-48.

Moïsi JC, SK Saha, AG Falade, BM Njanpop-Lafourcade, J Oundo, AKM Zaidi, S Afroj, RA Bakare, JK Buss, R Lasi, AA Odekanmi, L Sangaré, JAG Scott, MD Knoll, OS Levine and BD Gessner. Enhanced diagnosis of pneumococcal meningitis with use of the Binax NOW immunochromatographic test of Streptococcus pneumoniae antigen: a multisite study. Clin Infect Dis. 2009;48 Suppl 2:S49-56.

Levine OS, T Cherian, R Hajjeh, M Deloria Knoll. Progress and future challenges in coordinated surveillance and detection of pneumococcal and Hib disease in developing countries. Clin Infect Dis. 2009;48 Suppl 2:S33-6.

Shah AS, M Deloria Knoll, PR Sharma, P Kulkarni, JC Moïsi, MK Lalitha, M Steinhoff, K Thomas. Invasive pneumococcal disease in Kanti Children's Hospital, Nepal, as observed by the South Asian Pneumococcal Alliance network. Clin Infect Dis. 2009;48 Suppl 2:S123-8.

Sinha A, Levine OS, Knoll MD, Muhib F, Lieu TA. Cost-effectiveness of pneumococcal conjugate vaccination in the prevention of child mortality. Lancet 2007;369:389-96.

Levine OS, O'Brien KL, Knoll M, Adegbola RA, Black S, Cherian T, Dagan R, Goldblatt D, Grange A, Greenwood B, Hennessy T, Klugman KP, Madhi SA, Mulholland K, Nohynek H, Santosham M, Saha SK, Scott JA, Sow S, Whitney CG, Cutts F. Pneumococcal vaccination in developing countries. Lancet 2006;367:1880-2.

Deloria-Knoll M, M Steinhoff, R Semba, K Nelson, C Meinert. Effect of zinc and vitamin A supplementation on the antibody response to pneumococcal conjugate vaccine in HIV-positive injection drug users: a randomized trial. Vaccine 2006;24:1670-1679.

Achenbach CJ, M Till, FJ Palella, MD Knoll, SM Terp, AU Kalnins, RL Murphy. Extended antiretroviral treatment interruption in HIV-infected patients with long-term suppression of plasma HIV RNA. HIV Med 2005;6:7-12.

Rozovsky-Weinberger J, JP Parada, L Phan, DG Droller, M Deloria-Knoll, JS Chmiel, CL Bennet. Delays in suspicion and isolation among hospitalized persons with pulmonary tuberculosis at public and private US hospitals during 1996 to 1999. Chest 2005;127:205-12.

Deloria-Knoll M, JS Chmiel, AC Moorman, KC Wood, SD Holmberg, and FJ Palella Jr. Factors related to and consequences of adherence to antiretroviral therapy in ambulatory HIV patients. AIDS Patient Care STDs 2004;18:721-727.

Le T, JD Cherry, SJ Chang, M Deloria Knoll, ML Lee, S Barenkamp, D Bernsstein, R Edelman, KM Edwards, D Greenberg, W Keitel, J Treanor, J Ward. Immune responses and antibody decay after immunization of adolescents and adults with an acellular pertussis vaccine: the APERT study. JID 2004;190:535-544.

Uphold CR, M Deloria-Knoll, FJ Palella Jr, JP Parada, JS Chmiel, L Phan, CL Bennett. U.S. hospital care for patients with HIV infection and pneumonia: the role of public, private, and Veterans Affairs hospitals in the early highly active antiretroviral therapy era. Chest 2004;125:548-56.

Sureka A, JP Parada, M Deloria-Knoll, JS Chmiel, L Phan, TM Lyons, SN Ali, PR Yarnold, RA Weinstein, JA DeHovitz, JM Jacobson, MB Goetz, RE Campo, D Berland, CL Bennett, CR Uphold. HIV-related pneumonia care in older patients hospitalized in the early HAART era. AIDS Patient Care STDS 2004;18:99-107.

Arozullah AM, J Parada, CL Bennett, M Deloria-Knoll, JS Chmiel, L Phan, PR Yarnold. A rapid staging system for predicting mortality from HIV-associated community-acquired pneumonia. Chest 2003;123:1151-60.

Berger VW, A Ivanova, and MD Knoll. Minimizing predictability while retaining balance through less restrictive randomization procedures. Stat Med 2003;22:3017-28

Parada JP, M Deloria-Knoll, JS Chmiel, AM Arozullah, L Phan, SN Ali, MB Goetz, RA Weinstein, R Campo, J Jocobson, J Dehovitz, D Berland, CL Bennett. Relationship between health insurance and medical care for patients hospitalized with Human Immunodeficiency virus-related Pneumocystis carinii pneumonia, 1995-1997: Medicaid, bronchoscopy, and survival. Clin Infect Dis 2003;37 :1549-55.

Greenland P, MD Knoll, J Stamler, J Neaton AR Dyer, DB Garside, and PW Wilson. Major risk factors as antecedents of fatal and non-fatal coronary heart disease events. JAMA 2003;290:891-7.

Palella FJ Jr., M Deloria-Knoll, JS Chmiel, AC Moorman, KC Wood, AE Greenberg, and SD Holmberg. Survival benefit of initiating antiretroviral therapy in HIV-infected persons in different CD4+ cell strata. Ann Intern Med 2003;138:620-6.

Obaro SK, GC Enwere, M Deloria, S Jaffar, D Goldblatt, K Brainsby, H Hallander, P McInnes, BM Greenwood, and KPWJ McAdam. Safety and immunogenicity of pneumococcal conjugate vaccine in combination with diphtheria, tetanus toxoid, pertussis and Haemophilus influenzae type b conjugate vaccine. Pediatr Infect Dis J 2002;21:940-6.