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Faculty
Maria Wawer
Professor
Academic Degrees
MD, MHS
Departmental Address
Wolfe St. Building E4537
Phone: 410-955-1701
Research and Professional Experience

Co-founded, with Drs. David Serwadda and Nelson Sewankambo, the Rakai Health Sciences Program (RHSP), Rakai District, Uganda. Since 1988, the RHSP has conducted population-based cohort studies, prevention trials, clinical and laboratry research, and operations research on HIV and STI epidemiology, molecular epidemiology, risk factors, prevention, treatment, and social and demographic consequences. Trials have included STI control for HIV prevention, STI control during pregnancy for the prevention of mother-to-child HIV transmission, male circumcision for HIV prevention in men and male circumcision in HIV+ men for the prevention of HIV/STI transmission to women. Current interests also include the role of mucosal immunity in resistance/susceptibility to HIV infection.

Keywords

Rakai Health Sciences Program, HIV, HIV prevention, HPV, male circumcision, sexually transmitted infections, population-based cohort study

Selected Publications

Wawer, MJ, F Makumbi, G Kigozi, D Serwadda, S Watya,F Nalugoda, D Buwembo, V Ssempijja, N Kiwanuka, LH. Moulton, NK Sewankambo, SJ Reynolds, TC Quinn; R Ridzon, P Opendi,2 B Iga, and R H Gray.1 Trial of Male Circumcision in HIV-infected Men:Effects on HIV Transmission to Women Partners. Forthcoming, Lancet.

Tobian, AA., D Serwadda, TC Quinn , G Kigozi, PE. Gravitt, O Laeyendecker, B Charvat, V Ssempijja, M Riedesel, AE. Oliver, RG. Nowak, LH. Moulton, M Z. Chen, SJ. Reynolds, MJ Wawer, RH Gray. Efficacy of Male Circumcision for HSV-2, Syphilis and HPV Prevention. NEJM, 2009: 360: 1298-309.

Ruark A, JD Shelton, DT Halperin, MJ Wawer and RH Gray. Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet, 2009; 373: 1078

Redd, AD, D Dabitao, J Bream, B Charvat, O Laeyendecker, N Kiwanuka, T Lutalo, G Kigozi, AA Tobian, J Gamiel, JD Neal, AE Oliver, JB Margolick, N Sewankambo, SJ Reynolds, MJ Wawer, D Serwadda, RH Gray, TC Quinn. Microbial translocation, the innate cytokine repsonse and HIV-1 disease progression in Africa. Proc Natl Acad Sci USA 2009; 106: 6718-23.

Tobian AA, B Charvat, V Ssempijja, G Kigozi, D Serwadda, F Makumbi, B Iga, O Laeyenedecker, M Riedsesel, A Oliver, MZ Chen, S Reynolds, MJ Wawer, RH Gray and TC Quinn. J Infect Dis, 2009; epub ahead of print.

Kiggundu, V, S Watya, G Kigozi, D Serwadda, F Nalugoda, D Buwembo, A Settuba, M Anyokorit, J Nkale, N Kighoma, V Ssempijja, M Wawer, RH Gray. The number of procedures required to achieve optimal competency with male circumcision: findings form a randomized trial in Rakai, Uganda. Brit J Urology Int, 2009, Apr 17. (Epub ahead of print)

Sagar M, O Laeyendecker, S Lee, J Gamiel, MJ Wawer, R Gray, D Serwadda, NK Sewankambo, JC Shepherd, J Toma, WE Huang, TC Quinn, Selection of HIV variants with signature genotypic characteristics during heterosexual transmission. J Infect Dis. 2009; 199: 580-9.

Eshleman SH, O Laeyendecker, N Parkin, W Haung, C Chappey, A Paquet, D Serwadda, SJ Reynolds, N Kiwanuka, TC Quinn, RH Gray, MJ Wawer. Antiretroviral drug susceptibility among drug naïve adults with recent HIV infection in Rakai, Uganda. AIDS, 2009; 27: 845-52.

Gray RH, MJ Wawer, D Sewadda, G Kigozi. The role of male circumcision in the prevention of human papillomavirus and HIV prevention. JID, 2009; 199: 1-3..

Gray RH, Kigozi G, Serwadda D, Makumbi F, Nalugoda F, Watya S, Moulton L, Chen MZ, Sewankambo NK, Kiwanuka N, Sempijja V, Lutalo T, Kagayii J, Wabwire-Mangen F, Ridzon R, Bacon M, Wawer MJ. The effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda. Am J Obstet Gynecol. 2008 Oct 29. [Epub ahead of print]

Suntoke TR, A Hardick, AA tobian, B Mposa, O Laeynedecker, D Serwadda, CA Gaydos, RH Gray, MJ Wawer, RC Quinn, SJ Reynolds. Evaluation of multiplex real-time PCR fro the detection of H. Ducreyi, T. Pallidum, HSV-1, and HSSV-2 in the diagnosis of genital ulcer disease in Rakai District, Uganda. Sex Trans Infect, 2009; 85: 97-101.

Gray RH, Wawer MJ. Reassessing the hypothesis on STI control for HIV prevention. Lancet. 2008 Jun 21;371(9630):2064-5.

Kagaayi J, RH Gray, H Brahmbhatt, G Kigozi, F Nalugoda, F Wabwire-Mangen, D Serwadda, N Sewankambo, V Ddungu, D Ssebagala, J Sekasanvu, G Kigozi, F Makumib, N Kiwanuka, T Lutalo, SJ Reynolds, MJ Wawer. Survival of infants born to HIV-positive women, by feeding modality, Rakai , Uganda. Plos ONE, 2008: 3:e3877. Epub 2008 Dec 9.

Grady C, Wagman J, Ssekubugu R, Wawer MJ, Serwadda D, Kiddugavu M, Nalugoda F, Gray RH, Wendler D, Dong Q, Dixon DO, Townsend B, Wahl E, Emanuel EJ. Research benefits for hypothetical HIV vaccine trials: The views of Ugandans in the Rakai District. IRB. 2008 Mar-Apr;30(2):1-7.

Polis CB, T Lutalo, M Wawer, D Serwadda, G Kigozi, F Nalugoda, N Kiwanuka, R Gray. Coerced sexual debut and lifetime abortion attempts among women in Rakai, Uganda. Int J Gyn Obstet, 2008. (Epub ahead of print).

Wagman J, JN Baumgartner, CS Geary, N Nakyanjo, WG Ddaaki, D Serwadda, RJ Gray, FK Nalugoda, MJ Wawer. Experiences of sexual coercion among adolescent women: Qualitative findings form the Rakai District, Uganda. J Interpers Violence, 2008: Dec.

Gray RH, Wawer MJ, Kigozi G, Serwadda D. Commentary: Disease modelling to inform policy on male circumcision for HIV prevention. Int J Epidemiol. 2008 May 9.

Kigozi G, RH Gray, MJ Wawer, et al. The safety of male circumcision in HIV-infected and uninfected men, Rakai, Uganda. PLos Med, 2008. June 3: 5(6): e116.

Gray RH, Wawer MJ, Polis CB, Kigozi G, Serwadda D. Male Circumcision and Prevention of HIV and Sexually Transmitted Infections. Curr Infect Dis Rep. 2008 May;10(2):121-7.

Safaeian M, Kiduggavu M, Gravitt PE, Gange SJ, Ssekasanvu J, Muroka D, Sklar M, Serwada D, Wawer MJ, Shah KV, Gray R. Prevalence and risk factors for carcinogenic human papillomavirus infections in rural Rakai, Uganda. Sex Transm Infect. 2008 Apr 2. [Epub ahead of print]

Brahmbhatt H, Sullivan D, Kigozi G, Askin F, Wabwire-Mangenm F, Serwadda D, Sewankambo N, Wawer M, Gray R. Association of HIV and malaria with mother-to-child transmission, birth outcomes, and child mortality. J Acquir Immune Defic Syndr. 2008 Apr 1;47(4):472-6.

Kiwanuka N, Laeyendecker O, Robb M, Kigozi G, Arroyo M, McCutchan F, Eller LA, Eller M, Makumbi F, Birx D, Wabwire-Mangen F, Serwadda D, Sewankambo NK, Quinn TC, Wawer M, Gray R. Effect of Human Immunodeficiency Virus Type 1 (HIV-1) subtype on disease progression in persons from Rakai, Uganda, with incident HIV-1 infection. J Infect Dis. 2008 Mar 1;197(5):707-13.

Ssafaeian M, M Kiddugavu, PE Gravitt, SJ Gange, J Ssekasanvu, D Murokora, M Sklar, D Serwadda, MJ Wawer, KV Shah, R Gray. Determinants of incidence and clearance of high-risk human papillomavirus infections in rural Rakai, Uganda. Cancer Epidemiol Biomarkers Prev. 2008: 17(6): 1300-7.

Kigozi F, S Watya, CB Polis, D Buwembo, V Kiddugavu, MJ Wawer, D Serwadda, F Nalugoda, N Kiwanuka, MC Bacon, V Ssempijja, F Makumbi, RH Gray. The effect of male circumcision on sexual satisfaction and function: results from a randomized trial of male circumcision for HIV prevention, Rakai, Uganda. BJU Int, 2008: 101: 65-70.

Gray R, Wawer MJ. Randomised trials of HIV prevention (Comment) Lancet, 2007; 370: 200-1.

Gray R, Kigozi G, Serwadda D, Makumbi F, Wayta S, Nalugoda F, Kiwanuka N, Moulton L, Chaudhary M, Chen M, Sewankambo N, Wabwire-Mangen F, Bacon M, Williams C, Opendi P, Reynolds S, Laeyendecker O, Quinn T, Wawer MJ. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomized trial. Lancet 369 2007.657-666.

Lutalo T, Gray RH, Wawer M, Sewankambo N, Serwadda D, Laeyendecker O, Kiwanuka N, Nalugoda F, G Kigozi, A Ndyanabo, JB Bwanika, SJ Reynolds, T quinn, P Opendi. Survival of HIV-infected treatment naïve individuals with documented dates of seroconversion in Rakai, Uganda. AIDS, 2007, S6: S15-19.

Matovu J, Ssempijja V, Makumbi F, Gray RH, Kigozi G, Nalugoda F, Serwadda D, Wawer MJ. Sexually Transmitted Infection Management, Safer Sex Promotion and Voluntary HIV Counseling and Testing in the Male Circumcision Trial, Rakai, Uganda. Reproductive Health Matters 15 (29)2007 68-74.

Zablotska, IB, RH Gray, MA Koenig, D Serwadda, F Nalugoda, G Kigozi, N Sewankambo, T Lutalo, F Wabwire- Mangen, MJ Wawer. Alcohol use, intimate partner violence, sexual coercion and HIV among women aged 15-24, Rakai, Uganda. AIDS Behav 2007, Dec 7. (Epub ahead of print.)

Gray R, Li X, Kigozi G, Serwadda D, Nalugoda F, Watya S, Reynolds S, Wawer MJ. The impact of male circumcision in HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda. AIDS 2007 21 845-850

Lutalo T, Gray R, Wawer MJ, Sewankambo N, Serwadda D, Laeyendecker O, Kiwanuka N, Nalugoda F, Kigozi G, Ndyanabo A, Bwanika JB, Reynolds SJ, Quinn T Opendi P. Survival of HIV-infected treatment-naïve individuals with documented dates of seroconversion in Rakai, Uganda. AIDS 2007 21: S15-S19.

Kagaayi J, Makumbi F, Nakigozi G, Wawer MJ, Gray RH, Serwadda D, Reynolds SJ. WHO HIV Clinical Staging or CD4 counts for antiretroviral therapy eligibility assessment? An evaluation in Rural Rakai, District, Uganda. AIDS 2007;21: 1208-10.

Gray R, Makumbi F, Serwadda D, Lutalo, Nalugoda F, Opendi P, Kigozi G, Reynolds S, Sewankambo NK, Wawer MJ. Limitations of rapid HIV-1 tests during screening for trials in Uganda: diagnostic test accuracy study. BMJ (335) 2007.188-190.

Thiessen C, Ssekubugu, Wagman J, Kiddugavu, Wawer MJ, Emanuel E, Gray R, Serwadda D, Grady C. Personal and community benefits and harms of research: views from Rakai, Uganda AIDS 2007 21:2493-2501.

Brahmbhatt H, Sullivan D, Kigozi G, Askin F, Wabwire-Mangen F, Serwadda D, Sewankambo N, Wawer MJ, Gray R. Association of HIV and Malaria with MTCT, Birth Outcomes and Child Mortality. Forthcoming, 2007

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